An unexpected synthesis of β-amino-α-mesyl-γ-sultams upon mesylation of hindered α-aminonitriles
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DOI: 10.1007/s10593-020-02671-y
Abstract: We report one-pot procedure for an unexpected synthesis of previously unknown 4-amino-5-methylsulfonyl-2,3-dihydroisothiazole 1,1-dioxides (also called β-amino-α-mesyl-γ-sultams). Thus, the reaction of mesyl chloride with hindered α-aminonitriles is accompanied by the formation of interim N -(1-cyanoalkyl)(methylsulfonyl)methanesulfonamides which,… read more here.
Keywords: amino mesyl; amino; hindered aminonitriles; unexpected synthesis ... See more keywords