Tobacco smoking aggravates airway inflammation by upregulating endothelin-2 and activating the c-Jun amino terminal kinase pathway in asthma.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.105916
Abstract: BACKGROUND Asthma is closely associated with tobacco smoking (TS) and is more difficult to effectively treat after exposure to TS. OBJECTIVE To observe the effects of TS on the expression of endothelin-2 (ET-2) and airway… read more here.
Keywords: amino terminal; tobacco smoking; inflammation; airway inflammation ... See more keywords
Role of amino terminal substitutions in the pharmacological, rewarding and psychostimulant profiles of novel synthetic cathinones
Sign Up to like & getrecommendations! Published in 2021 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2021.108475
Abstract: The emergence of new synthetic cathinones continues to be a matter of public health concern. In fact, they are quickly replaced by new structurally related alternatives. The main goal of the present study was to… read more here.
Keywords: synthetic cathinones; role amino; amino terminal; novel synthetic ... See more keywords
Conformational rearrangement of the NMDA receptor amino-terminal domain during activation and allosteric modulation
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23024-z
Abstract: N-Methyl-D-aspartate receptors (NMDARs) are ionotropic glutamate receptors essential for synaptic plasticity and memory. Receptor activation involves glycine- and glutamate-stabilized closure of the GluN1 and GluN2 subunit ligand binding domains that is allosterically regulated by the… read more here.
Keywords: terminal domain; amino terminal; separation; activation ... See more keywords
Amino terminal modifications, the associated processing machinery, and their evolution in plastid-containing organisms.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of experimental botany"
DOI: 10.1093/jxb/erac290
Abstract: The N-terminus is a frequent site of protein modifications. Referring primarily to knowledge gained from land plants, here we review the modifications that change protein amino terminal residues and provide updated information about the associated… read more here.
Keywords: plastid containing; terminal modifications; amino terminal; machinery ... See more keywords
An amino-terminal fragment of apolipoprotein E4 leads to behavioral deficits, increased PHF-1 immunoreactivity, and mortality in zebrafish
Sign Up to like & getrecommendations! Published in 2022 at "PLOS ONE"
DOI: 10.1371/journal.pone.0271707
Abstract: Although the increased risk of developing sporadic Alzheimer’s disease (AD) associated with the inheritance of the apolipoprotein E4 (APOE4) allele is well characterized, the molecular underpinnings of how ApoE4 imparts risk remains unknown. Enhanced proteolysis… read more here.
Keywords: treatment napoe41; fragment; napoe41 151; amino terminal ... See more keywords
Spinocerebellar Ataxia Type 31 Exacerbated by Anti-amino Terminal of Alpha-enolase Autoantibodies
Sign Up to like & getrecommendations! Published in 2022 at "Internal Medicine"
DOI: 10.2169/internalmedicine.8883-21
Abstract: We herein report a 61-year-old woman who was genetically diagnosed with spinocerebellar ataxia type 31 whose symptoms were modified by anti-amino terminal of alpha-enolase (NAE) antibodies, known as a biomarker of Hashimoto's encephalopathy (HE), and… read more here.
Keywords: anti amino; ataxia type; amino terminal; spinocerebellar ataxia ... See more keywords
Synthesis, antifungal activity and potential mechanism of fusidic acid derivatives possessing amino-terminal groups.
Sign Up to like & getrecommendations! Published in 2020 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2019-0289
Abstract: Aim: Fusidic acid (FA) is a narrow-spectrum bacteriostatic antibiotic. We inadvertently discovered that a FA derivative modified by an amino-terminal group at the 3-OH position, namely 2, inhibited the growth of Cryptococcus neoformans. Methods &… read more here.
Keywords: amino terminal; derivatives possessing; antifungal activity; fusidic acid ... See more keywords
Can NT-pro BNP Levels Predict Prognosis of Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease in the Intensive Care Unit?
Sign Up to like & getrecommendations! Published in 2018 at "Balkan Medical Journal"
DOI: 10.4274/balkanmedj.2018.0006
Abstract: Background: The prognostic value of amino terminal pro-brain natriuretic peptide levels in patients with acute exacerbation of chronic obstructive pulmonary disease has not been fully established. Aims: To investigate the predictive value of amino terminal… read more here.
Keywords: brain natriuretic; terminal pro; ventilation; amino terminal ... See more keywords