2-Amino-1,3,4-thiadiazoles as Glutaminyl Cyclases Inhibitors Increase Phagocytosis through Modification of CD47-SIRPĪ± Checkpoint.
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DOI: 10.1021/acsmedchemlett.2c00256
Abstract: Glutaminyl cyclases (QC, isoQC) convert N-terminal glutamine or glutamate into pyroglutamate (pGlu) on substrates. IsoQC has recently been demonstrated to promote pGlu formation on the N-terminus of CD47, the SIRPĪ± binding site, contributing to the… read more here.
Keywords: modification; glutaminyl cyclases; cd47; cd47 sirp ... See more keywords