New Efficient Synthesis of tRNA Related Adenosines Bearing the Hydantoin Ring (ct6A, ms2ct6A) by Intramolecular Cyclization of N6‐(N‐Boc‐α‐aminoacyl)‐adenosine Derivatives
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DOI: 10.1002/cbic.202100655
Abstract: A novel and efficient way for the synthesis of N6‐hydantoin‐modified adenosines, which utilizes readily available N6‐(N‐Boc‐α‐aminoacyl)‐adenosine derivatives, was developed. The procedure is based on the epimerization‐free, Tf2O‐mediated conversion of the Boc group into an isocyanate… read more here.
Keywords: aminoacyl adenosine; adenosine derivatives; boc; hydantoin ... See more keywords