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Published in 2021 at "Protein Science"
DOI: 10.1002/pro.4148
Abstract: Malaria is a parasitic illness caused by the genus Plasmodium from the apicomplexan phylum. Five plasmodial species of P. falciparum (Pf), P. knowlesi, P. malariae, P. ovale, and P. vivax (Pv) are responsible for causing…
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Keywords:
structural analyses;
antimalarial drug;
drug;
trna synthetases ... See more keywords
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Published in 2019 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1564
Abstract: Aminoacyl tRNA synthetases (aaRS) are well studied for their roles in tRNA charging with cognate amino acid. Nevertheless, numerous lines of evidence indicate that these proteins have roles other than tRNA charging. These include coordination…
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Keywords:
transcriptional regulation;
post transcriptional;
trna synthetases;
aminoacyl trna ... See more keywords
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Published in 2018 at "Biochimie"
DOI: 10.1016/j.biochi.2017.12.006
Abstract: Aminoacyl-tRNA synthetases (aaRSs) decode genetic information by coupling tRNAs with cognate amino acids. In the archaeon Methanothermobacter thermautotrophicus arginyl- and seryl-tRNA synthetase (ArgRS and SerRS, respectively) form a complex which enhances serylation and facilitates tRNASer…
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Keywords:
trnaarg;
serrs;
aminoacyl trna;
trna synthetase ... See more keywords
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Published in 2018 at "Drug discovery today"
DOI: 10.1016/j.drudis.2018.01.050
Abstract: Malaria remains a major infectious disease and, despite incidence reduction, it threatens resurgence in drug-resistant forms. Antimalarial drugs remain the mainstay of therapeutic options and hence there is a constant need to identify and validate…
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Keywords:
drug;
plasmodium falciparum;
malaria;
aminoacyl trna ... See more keywords
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Published in 2022 at "Translational Oncology"
DOI: 10.1016/j.tranon.2022.101392
Abstract: Highlights • Aminoacyl-tRNA synthetases (AARSs) of multi-tRNA synthetase complex (MSC) are involved in cancer pathogenesis.• The scaffolding proteins of MSC have mainly anti-tumorigenic functions whereas the MSC associated AARSs have pro-tumorigenic roles.• MSC release of…
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Keywords:
multi trna;
aminoacyl trna;
trna synthetases;
trna synthetase ... See more keywords
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Published in 2017 at "Methods"
DOI: 10.1016/j.ymeth.2016.11.014
Abstract: Aminoacyl-tRNA synthetases (aaRSs) are enzymes that function at the first step of translation, catalyzing the conjugation of amino acids to their cognate tRNAs for protein synthesis. While preserving this essential role, higher eukaryotic aaRSs, such…
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Keywords:
nontranslational functions;
trna synthetases;
aminoacyl trna;
translational nontranslational ... See more keywords
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Published in 2021 at "Molecular genetics and metabolism"
DOI: 10.1016/j.ymgme.2021.04.004
Abstract: BACKGROUND AND PURPOSE Mitochondrial aminoacyl-tRNA synthetases-encoded by ARS2 genes-are evolutionarily conserved enzymes that catalyse the attachment of amino acids to their cognate tRNAs, ensuring the accuracy of the mitochondrial translation process. ARS2 gene mutations are…
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Keywords:
brain mri;
aminoacyl trna;
mri;
mitochondrial aminoacyl ... See more keywords
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Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c03441
Abstract: The inhibitory effect of tavaborole on the invasion of Botrytis cinerea in grapes and tomatoes, as well as the potential mechanism involved, was discovered in this study. Our findings showed that tavaborole inhibited Botrytis cinerea…
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Keywords:
botrytis;
fruit;
botrytis cinerea;
trna biosynthesis ... See more keywords
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Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00134
Abstract: Aminoacyl-tRNA synthetases (aaRSs) are promising drug targets due to their essential roles in protein translation. Although current inhibitors primarily occupy one or two of the three substrate binding sites on aaRSs, we report here the…
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Keywords:
aminoacyl trna;
triple site;
proof concept;
site ... See more keywords
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Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.3c00826
Abstract: The ensemble of aminoacyl tRNA synthetases is regarded as a key component of the protein translation machinery. With the progressive increase in structure-based studies on tRNA synthetase-ligand complexes, the detailed picture of these enzymes is…
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Keywords:
structural biology;
trypanosomatid;
development;
trna synthetases ... See more keywords
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Published in 2017 at "Nature chemical biology"
DOI: 10.1038/nchembio.2474
Abstract: Directed evolution of orthogonal aminoacyl-tRNA synthetases (AARSs) enables site-specific installation of non-canonical amino acids (ncAAs) into proteins. Traditional evolution techniques typically produce AARSs with greatly reduced activity and selectivity compared to their wild-type counterparts. We…
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Keywords:
directed evolution;
trna synthetases;
aminoacyl trna;
evolution ... See more keywords