A Potential Role for Aminoacylation in Primordial RNA Copying Chemistry.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry"
DOI: 10.1021/acs.biochem.0c00943
Abstract: Aminoacylated tRNAs are the substrates for ribosomal protein synthesis in all branches of life, implying an ancient origin for aminoacylation chemistry. In the 1970s, Orgel and colleagues reported potentially prebiotic routes to aminoacylated nucleotides and… read more here.
Keywords: rna replication; chemistry; role aminoacylation; aminoacylation ... See more keywords
Principles of chemical geometry underlying chiral selectivity in RNA minihelix aminoacylation
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky909
Abstract: Abstract The origin of homochirality in L-amino acid in proteins is one of the mysteries of the evolution of life. Experimental studies show that a non-enzymatic aminoacylation reaction of an RNA minihelix has a preference… read more here.
Keywords: rna minihelix; rna; geometry; aminoacylation ... See more keywords
Prebiotic Assembly of Cloverleaf tRNA, Its Aminoacylation and the Origin of Coding, Inferred from Acceptor Stem Coding-Triplets
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232415756
Abstract: tRNA is a key component in life’s most fundamental process, the translation of the instructions contained in mRNA into proteins. Its role had to be executed as soon as the earliest translation emerged, but the… read more here.
Keywords: aminoacylation; stem coding; aminoacylation origin; acceptor ... See more keywords