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   Articles with "aminoacylation" as a keyword



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A Potential Role for Aminoacylation in Primordial RNA Copying Chemistry.

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recommendations! Published in 2021 at "Biochemistry"

DOI: 10.1021/acs.biochem.0c00943

Abstract: Aminoacylated tRNAs are the substrates for ribosomal protein synthesis in all branches of life, implying an ancient origin for aminoacylation chemistry. In the 1970s, Orgel and colleagues reported potentially prebiotic routes to aminoacylated nucleotides and… read more here.

Keywords: rna replication; chemistry; role aminoacylation; aminoacylation ... See more keywords

Thioester-mediated RNA aminoacylation and peptidyl-RNA synthesis in water

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recommendations! Published in 2025 at "Nature"

DOI: 10.1038/s41586-025-09388-y

Abstract: To orchestrate ribosomal peptide synthesis, transfer RNAs (tRNAs) must be aminoacylated, with activated amino acids, at their 2′,3′-diol moiety1,2, and so the selective aminoacylation of RNA in water is a key challenge that must be… read more here.

Keywords: rna aminoacylation; water; peptidyl rna; synthesis ... See more keywords

Structural basis for aminoacylation of cellular modified tRNALys3 by human lysyl-tRNA synthetase

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recommendations! Published in 2025 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkaf114

Abstract: Abstract The average eukaryotic transfer ribonucleic acid (tRNA) contains 13 post-transcriptional modifications; however, their functional impact is largely unknown. Our understanding of the complex tRNA aminoacylation machinery in metazoans also remains limited. Herein, using a… read more here.

Keywords: trna; trna synthetase; human lysyl; lysyl trna ... See more keywords

Principles of chemical geometry underlying chiral selectivity in RNA minihelix aminoacylation

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recommendations! Published in 2018 at "Nucleic Acids Research"

DOI: 10.1093/nar/gky909

Abstract: Abstract The origin of homochirality in L-amino acid in proteins is one of the mysteries of the evolution of life. Experimental studies show that a non-enzymatic aminoacylation reaction of an RNA minihelix has a preference… read more here.

Keywords: rna minihelix; rna; geometry; aminoacylation ... See more keywords

Prebiotic Assembly of Cloverleaf tRNA, Its Aminoacylation and the Origin of Coding, Inferred from Acceptor Stem Coding-Triplets

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms232415756

Abstract: tRNA is a key component in life’s most fundamental process, the translation of the instructions contained in mRNA into proteins. Its role had to be executed as soon as the earliest translation emerged, but the… read more here.

Keywords: aminoacylation; stem coding; aminoacylation origin; acceptor ... See more keywords