Design, synthesis and biological evaluation of novel naphthoquinone-4-aminobenzensulfonamide/carboxamide derivatives as proteasome inhibitors.
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DOI: 10.1016/j.ejmech.2020.112890
Abstract: A series of novel 4-aminobenzensulfonamide/carboxamide derivatives bearing naphthoquinone pharmacophore were designed, sythesized and evaluated for their proteasome inhibitory and antiproliferative activities against human breast cancer cell line (MCF-7). The structures of the synthesized compounds were… read more here.
Keywords: design synthesis; carboxamide derivatives; aminobenzensulfonamide carboxamide; inhibitory activity ... See more keywords