Severe Intellectual Disability and Enhanced Gamma-Aminobutyric Acidergic Synaptogenesis in a Novel Model of Rare RASopathies
Sign Up to like & getrecommendations! Published in 2017 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2016.06.016
Abstract: BACKGROUND Dysregulation of Ras-extracellular signal-related kinase (ERK) signaling gives rise to RASopathies, a class of neurodevelopmental syndromes associated with intellectual disability. Recently, much attention has been directed at models bearing mild forms of RASopathies whose… read more here.
Keywords: gamma aminobutyric; intellectual disability; synaptogenesis; model ... See more keywords
Prognostic value of γ‐aminobutyric acidergic synapse-associated signature for lower-grade gliomas
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.983569
Abstract: Background Synapse-associated proteins (SAPs) play important roles in central nervous system (CNS) tumors. Recent studies have reported that γ-aminobutyric acidergic (GABAergic) synapses also play critical roles in the development of gliomas. However, biomarkers of GABAergic… read more here.
Keywords: grade gliomas; aminobutyric acidergic; synapse associated; risk ... See more keywords