High-yielding synthesis of N-triazolyl carboxamides via palladium-catalysed aminocarbonylation
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2017.10.017
Abstract: Abstract Aminocarbonylation of alkenyl and aryl iodides in the presence of 4-amino-4H-1,2,4-triazole as N-nucleophile was carried out in the presence of palladium catalysts. Both types of substrates have shown high chemoselectivity toward carboxamides, i.e. practically… read more here.
Keywords: triazolyl carboxamides; high yielding; synthesis triazolyl; yielding synthesis ... See more keywords
Ligands and Bases Mediate Switching between Aminocarbonylations and Alkoxycarbonylations in Coupling of Aminophenols with Iodoarenes.
Sign Up to like & getrecommendations! Published in 2019 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.9b01392
Abstract: The mechanisms of aminocarbonylations and alkoxycarbonylations in coupling of aminophenols with iodoarenes catalyzed by the bidentate phosphorus ligand Pd complexes were explored with theoretical calculations. The origins of chemoselective carbonylation mediated by ligands and bases… read more here.
Keywords: coupling aminophenols; alkoxycarbonylations coupling; aminocarbonylations alkoxycarbonylations; ligands bases ... See more keywords
Palladium-catalyzed aminocarbonylation of halo-substituted 7-azaindoles and other heteroarenes using chloroform as a carbon monoxide source.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc04339b
Abstract: A palladium-catalyzed aminocarbonylation of halo-substituted 7-azaindoles utilizing CHCl3 as the carbonyl source has been developed for the straightforward incorporation of an amide functional group. The protocol was extended to other heteroarenes such as pyrazolopyridines and… read more here.
Keywords: halo substituted; catalyzed aminocarbonylation; palladium catalyzed; aminocarbonylation ... See more keywords
Selective Synthesis of N-Acylnortropane Derivatives in Palladium-Catalysed Aminocarbonylation
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26061813
Abstract: The aminocarbonylation of various alkenyl and (hetero)aryl iodides was carried out using tropane-based amines of biological importance, such as 8-azabicyclo[3.2.1]octan-3-one (nortropinone) and 3α-hydroxy-8-azabicyclo[3.2.1]octane (nortropine) as N-nucleophile. Using iodoalkenes, the two nucleophiles were selectively converted to… read more here.
Keywords: derivatives palladium; selective synthesis; acylnortropane derivatives; synthesis acylnortropane ... See more keywords