PdCl2-catalyzed synthesis of a new class of isocoumarin derivatives containing aminosulfonyl / aminocarboxamide moiety: First identification of a isocoumarin based PDE4 inhibitor.
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DOI: 10.1016/j.ejmech.2021.113514
Abstract: While anti-inflammatory properties of isocoumarins are known their PDE4 inhibitory potential was not explored previously. In our effort the non-PDE4 inhibitor isocoumarins were transformed into the promising inhibitors via introducing an aminosulfonyl/aminocarboxamide moiety to the… read more here.
Keywords: pde4 inhibitor; aminocarboxamide moiety; moiety; aminosulfonyl aminocarboxamide ... See more keywords