On the Role of DT-Diaphorase Inhibition in Aminochrome-Induced Neurotoxicity In Vivo
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DOI: 10.1007/s12640-017-9719-8
Abstract: Dopamine oxidation in the pathway leading to neuromelanin formation generates the ortho-quinone aminochrome, which is potentially neurotoxic but normally rapidly converted by DT-diaphorase to nontoxic leukoaminochrome. However, when administered exogenously into rat striatum, aminochrome is… read more here.
Keywords: diaphorase inhibition; role diaphorase; aminochrome; neurotoxicity ... See more keywords