Sprayable Antibacterial Hydrogels by Simply Mixing of Aminoglycoside Antibiotics and Cellulose Nanocrystals for the Treatment of Infected Wounds (Adv. Healthcare Mater. 20/2022)
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202201286
Abstract: Antibiotic hydrogels with sustained release profiles were recognized as promising candidates to treat local bacterial infections with reduced adverse effects. However, it still remains challenging for clinical translation of these antibiotic gels due to safety… read more here.
Keywords: simply mixing; hydrogels simply; treatment; aminoglycoside antibiotics ... See more keywords
Structure‐Activity Relationships for 5′′ Modifications of 4,5‐Aminoglycoside Antibiotics
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200120
Abstract: Modification at the 5’’‐position of 4,5‐disubstituted aminoglycoside antibiotics (AGAs) to circumvent inactivation by aminoglycoside modifying enzymes (AMEs) is well known. Such modifications, however, unpredictably impact activity and affect target selectivity thereby hindering drug development. A… read more here.
Keywords: structure activity; activity; activity relationships; aminoglycoside antibiotics ... See more keywords
Use of aminoglycoside antibiotics in equine clinical practice; a questionnaire‐based study of current use
Sign Up to like & getrecommendations! Published in 2020 at "Veterinary Medicine and Science"
DOI: 10.1002/vms3.382
Abstract: Abstract Veterinary use of the aminoglycoside antibiotics is under increasing scrutiny. This questionnaire‐based study aimed to document the use of aminoglycosides with a particular focus on gentamicin. An online questionnaire was delivered to generalist equine… read more here.
Keywords: medicine; administration; aminoglycoside antibiotics; gentamicin ... See more keywords
Chemical Modifications Reduce Auditory Cell Damage Induced by Aminoglycoside Antibiotics.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b12420
Abstract: Although aminoglycoside antibiotics are effective against Gram-negative infections, these drugs often cause irreversible hearing damage. Binding to the decoding site of eukaryotic ribosomes appears to result in ototoxicity, but there is evidence that other effects… read more here.
Keywords: aminoglycoside antibiotics; reduce auditory; chemical modifications; auditory cell ... See more keywords
Pseudomonas aeruginosa Phosphate Transporter PitA (PA4292) Controls Susceptibility to Aminoglycoside Antibiotics by Regulating the Proton Motive Force
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00992-22
Abstract: Pseudomonas aeruginosa is an opportunistic Gram-negative bacterium that causes nosocomial infections in immunocompromised patients. β-lactam and aminoglycoside antibiotics are commonly used in the treatment of P. aeruginosa infections. Previously, we found that mutation in a… read more here.
Keywords: phosphate; pseudomonas aeruginosa; pa4292; phosphate transporter ... See more keywords
Pseudomonas aeruginosa Polynucleotide Phosphorylase Controls Tolerance to Aminoglycoside Antibiotics by Regulating the MexXY Multidrug Efflux Pump
Sign Up to like & getrecommendations! Published in 2020 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01846-20
Abstract: Pseudomonas aeruginosa is an opportunistic pathogen that shows high intrinsic resistance to a variety of antibiotics. The MexX-MexY-OprM efflux pump plays an important role in bacterial resistance to aminoglycoside antibiotics. ABSTRACT Pseudomonas aeruginosa is an… read more here.
Keywords: efflux pump; aminoglycoside antibiotics; tolerance; pseudomonas aeruginosa ... See more keywords
The ABC-Type Efflux Pump MacAB Is Involved in Protection of Serratia marcescens against Aminoglycoside Antibiotics, Polymyxins, and Oxidative Stress
Sign Up to like & getrecommendations! Published in 2021 at "mSphere"
DOI: 10.1128/msphere.00033-21
Abstract: The opportunistic pathogen Serratia marcescens can cause urinary tract infections, respiratory infections, meningitis, and sepsis in immunocompromised individuals. These infections are challenging to treat due to the intrinsic resistance of S. marcescens to an extensive… read more here.
Keywords: protection; pump; serratia marcescens; macab ... See more keywords
4F-Indole Enhances the Susceptibility of Pseudomonas aeruginosa to Aminoglycoside Antibiotics
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.04519-22
Abstract: Infections caused by Pseudomonas aeruginosa have become a major public health crisis. Its resistance to existing antibiotics causes clinical infections that are hard to cure. In this study, we found that halogenated indoles in combination… read more here.
Keywords: infections caused; pseudomonas aeruginosa; aeruginosa pao1; regulatory effect ... See more keywords
Host metabolites stimulate the bacterial proton motive force to enhance the activity of aminoglycoside antibiotics
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1007697
Abstract: Antibiotic susceptibility of bacterial pathogens is typically evaluated using in vitro assays that do not consider the complex host microenvironment. This may help explaining a significant discrepancy between antibiotic efficacy in vitro and in vivo,… read more here.
Keywords: activity aminoglycoside; aminoglycoside antibiotics; host; proton motive ... See more keywords
Antibiotic Combination Therapy: A Strategy to Overcome Bacterial Resistance to Aminoglycoside Antibiotics
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.839808
Abstract: After the first aminoglycoside antibiotic streptomycin being applied in clinical practice in the mid-1940s, aminoglycoside antibiotics (AGAs) are widely used to treat clinical bacterial infections and bacterial resistance to AGAs is increasing. The bacterial resistance… read more here.
Keywords: combination; resistance; bacterial resistance; agas ... See more keywords
Discovery of Novel Resistance Mechanisms of Vibrio parahaemolyticus Biofilm against Aminoglycoside Antibiotics
Sign Up to like & getrecommendations! Published in 2023 at "Antibiotics"
DOI: 10.3390/antibiotics12040638
Abstract: Inappropriate use of antibiotics eventually leads to the emergence of antibiotic-resistant strains and invalidates the treatment of infectious diseases. Aminoglycoside antibiotics (AGAs) are a class of broad-spectrum cationic antibiotics widely used for the treatment of… read more here.
Keywords: parahaemolyticus biofilm; parahaemolyticus; vibrio parahaemolyticus; resistance ... See more keywords