Aminoglycoside-modifying enzyme and 16S ribosomal RNA methyltransferase genes among a global collection of Gram-negative isolates.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of global antimicrobial resistance"
DOI: 10.1016/j.jgar.2018.10.020
Abstract: OBJECTIVES The prevalence of genes encoding aminoglycoside-modifying enzymes (AMEs) and 16S rRNA methyltransferases among 200 Gram-negative clinical isolates resistant to different aminoglycosides and collected worldwide during 2013 was evaluated. METHODS Selected AMEs and 16S rRNA… read more here.
Keywords: gram negative; methyltransferase; methyltransferase genes; 16s rrna ... See more keywords
Association of blaNDM-1 with blaKPC-2 and aminoglycoside-modifying enzymes genes among Klebsiella pneumoniae, Proteus mirabilis and Serratia marcescens clinical isolates in Brazil.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of global antimicrobial resistance"
DOI: 10.1016/j.jgar.2019.08.026
Abstract: OBJECTIVE Carbapenemase producingEnterobacterales are often involved in healthcare-associated infections worldwide. Therefore, the objective of this study was to investigate the frequency of the main genes for carbapenemases, methylases, aminoglycoside-modifying enzymes (AMEs), and mcr gene, as… read more here.
Keywords: blandm blakpc; modifying enzymes; aminoglycoside modifying; mirabilis ... See more keywords
Distribution of Aminoglycoside-Modifying Enzymes and Molecular Analysis of the Coagulase Gene in Clinical Isolates of Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus.
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DOI: 10.1089/mdr.2017.0121
Abstract: Enzymatic alteration of aminoglycosides by aminoglycoside-modifying enzymes (AMEs) is the major mechanism of resistance to aminoglycosides. The purpose of this study was to determine the frequency of AME genes, staphylococcal chromosomal cassette mec (SCCmec) types,… read more here.
Keywords: analysis; aureus; aminoglycoside modifying; resistance ... See more keywords
Ecology, more than antibiotics consumption, is the major predictor for the global distribution of aminoglycoside-modifying enzymes
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DOI: 10.1101/2022.01.07.475340
Abstract: Antibiotics consumption and its abuses have been historically and repeatedly pointed out as the major driver of antibiotic resistance emergence and propagation. However, several examples show that resistance may persist despite substantial reductions in antibiotic… read more here.
Keywords: antibiotics consumption; ecology; consumption; modifying enzymes ... See more keywords
Role of aminoglycoside-modifying enzymes and 16S rRNA methylase (ArmA) in resistance of Acinetobacter baumannii clinical isolates against aminoglycosides
Sign Up to like & getrecommendations! Published in 2021 at "Revista da Sociedade Brasileira de Medicina Tropical"
DOI: 10.1590/0037-8682-0599-2020
Abstract: Abstract INTRODUCTION: This study aimed to determine the role of genes encoding aminoglycoside-modifying enzymes (AMEs) and 16S rRNA methylase (ArmA) in Acinetobacter baumannii clinical isolates. METHODS: We collected 100 clinical isolates of A. baumannii and… read more here.
Keywords: modifying enzymes; arma; 16s rrna; aminoglycoside modifying ... See more keywords
Prevalence of Aminoglycoside Resistance and Aminoglycoside Modifying Enzymes in Acinetobacter baumannii Among Intensive Care Unit Patients, Ismailia, Egypt
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DOI: 10.2147/idr.s290584
Abstract: Background Acinetobacter baumannii is an opportunistic pathogen that rapidly develops antibiotic resistance against commonly prescribed antimicrobial agents in hospitalized patients worldwide. Aminoglycosides are commonly used in the treatment of A. baumannii health care-associated infections (HAIs).… read more here.
Keywords: care; baumannii; modifying enzymes; resistance ... See more keywords
Artemisinin derivative DHA27 enhances the antibacterial effect of aminoglycosides against Pseudomonas aeruginosa by inhibiting mRNA expression of aminoglycoside-modifying enzymes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.970400
Abstract: Bacterial resistance is becoming increasingly serious, the present study aimed to investigate the mechanism of antibacterial sensitization effect of DHA27 combined with tobramycin in tobramycin-resistant Pseudomonas aeruginosa (PA). We found that DHA27 combined with aminoglycosides… read more here.
Keywords: effect; antibacterial sensitization; dha27; aminoglycoside modifying ... See more keywords
Aminoglycoside-Modifying Enzymes Are Sufficient to Make Pseudomonas aeruginosa Clinically Resistant to Key Antibiotics
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DOI: 10.3390/antibiotics11070884
Abstract: Aminoglycosides are widely used to treat infections of Pseudomonas aeruginosa. Genes encoding aminoglycoside-modifying enzymes (AMEs), acquired by horizontal gene transfer, are commonly associated with aminoglycoside resistance, but their effects have not been quantified. The aim… read more here.
Keywords: pseudomonas aeruginosa; aminoglycoside modifying; resistance; modifying enzymes ... See more keywords