Population-based inference of aminoglycoside resistance mechanisms in Escherichia coli
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.07.020
Abstract: Background Interpretative reading of antimicrobial susceptibility test (AST) results allows inferring biochemical resistance mechanisms from resistance phenotypes. For aminoglycosides, however, correlations between resistance pathways inferred on the basis of the European Committee on Antimicrobial Susceptibility… read more here.
Keywords: mechanisms escherichia; aminoglycoside resistance; resistance mechanisms; resistance ... See more keywords
High prevalence of carbapenamase genes, AmpC genes and aminoglycoside resistance genes in extended spectrum β-lactamase positive uropathogens from Northern India.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of global antimicrobial resistance"
DOI: 10.1016/j.jgar.2019.07.029
Abstract: BACKGROUND In this study, we investigated the occurrence of Extended Spectrum β lactamase (ESBL) genes coexisting with carbapenemase, AmpC and aminoglycoside resistance gene in uropathogens. METHODS The antimicrobial susceptibility testing was performed by Kirby Bauer… read more here.
Keywords: spectrum lactamase; prevalence; aminoglycoside resistance; resistance ... See more keywords
Public health implications of plasmid-mediated quinolone and aminoglycoside resistance genes in Escherichia coli inhabiting a major anthropogenic river of India
Sign Up to like & getrecommendations! Published in 2022 at "Epidemiology and Infection"
DOI: 10.1017/s095026882200053x
Abstract: Abstract Presence of antimicrobial resistance (AMR) genes in Escherichia coli inhabiting anthropogenic rivers is an important public health concern because plasmid-mediated AMR genes can easily spread to other pathogens by horizontal gene transfer. Besides β-lactams,… read more here.
Keywords: genes escherichia; plasmid mediated; resistance; amr genes ... See more keywords
Natural Alkaloid Berberine Activity against Pseudomonas aeruginosa MexXY-Mediated Aminoglycoside Resistance: In Silico and in Vitro Studies.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.9b00317
Abstract: The multidrug efflux system MexXY-OprM, inside the resistance-nodulation-division family, is a major determinant of aminoglycoside resistance in Pseudomonas aeruginosa. In the fight aimed to identify potential efflux pump inhibitors among natural compounds, the alkaloid berberine… read more here.
Keywords: pseudomonas aeruginosa; aminoglycoside resistance; activity; alkaloid berberine ... See more keywords
Mechanisms of Fluoroquinolone and Aminoglycoside Resistance in Keratitis-Associated Pseudomonas aeruginosa.
Sign Up to like & getrecommendations! Published in 2019 at "Microbial drug resistance"
DOI: 10.1089/mdr.2018.0218
Abstract: Global emergence of multidrug resistant (MDR) strains limits therapeutic efficacy in Pseudomonas aeruginosa corneal ulcers. Identifying the primary causal factors of resistance shall improve clinical management. In this study, we sought to identify the underlying… read more here.
Keywords: pseudomonas aeruginosa; fluoroquinolone aminoglycoside; aminoglycoside resistance; resistance ... See more keywords
Whole-genome sequencing and transcriptome-characterized in vitro evolution of aminoglycoside resistance in Mycobacterium tuberculosis.
Sign Up to like & getrecommendations! Published in 2023 at "Microbial genomics"
DOI: 10.1099/mgen.0.001022
Abstract: Antibiotic resistance of Mycobacterium tuberculosis (Mtb) is a major public health concern worldwide. Therefore, it is of great significance to characterize the mutational pathways by which susceptible Mtb evolves into drug resistance. In this study,… read more here.
Keywords: resistance mycobacterium; tuberculosis; mtb; resistance ... See more keywords
Mutation to ispA Produces Stable Small-Colony Variants of Pseudomonas aeruginosa That Have Enhanced Aminoglycoside Resistance
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00621-22
Abstract: Pseudomonas aeruginosa is a major pathogen in burn wound infections. We present one of the first reports of small-colony variant (SCV) emergence of P. aeruginosa, taken from a patient under aminoglycosides for a persistent burn… read more here.
Keywords: small colony; mutation; aminoglycoside resistance; pseudomonas aeruginosa ... See more keywords
Whole-Genome Sequence Analysis of Multidrug-Resistant Campylobacter Isolates: a Focus on Aminoglycoside Resistance Determinants
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Microbiology"
DOI: 10.1128/jcm.00390-18
Abstract: A whole-genome sequencing (WGS) approach was conducted in order to identify the molecular determinants associated with antimicrobial resistance in 12 multidrug-resistant Campylobacter jejuni and Campylobacter coli isolates, with a focus on aminoglycoside resistance determinants. Two… read more here.
Keywords: whole genome; resistance determinants; aminoglycoside resistance; resistance ... See more keywords
High-Level Aminoglycoside Resistance in Human Clinical Klebsiella pneumoniae Complex Isolates and Characteristics of armA-Carrying IncHI5 Plasmids
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2021.636396
Abstract: Aminoglycosides are important options for treating life-threatening infections. However, high levels of aminoglycoside resistance (HLAR) among Klebsiella pneumoniae isolates have been observed to be increasing frequently. In this study, a total of 292 isolates of… read more here.
Keywords: pneumoniae complex; inchi5 plasmids; aminoglycoside resistance; resistance ... See more keywords
Insights into mobile genetic elements and the role of conjugative plasmid in transferring aminoglycoside resistance in extensively drug-resistant Acinetobacter baumannii AB329
Sign Up to like & getrecommendations! Published in 2022 at "PeerJ"
DOI: 10.7717/peerj.13718
Abstract: Acinetobacter baumannii is a major cause of nosocomial infection, and the incidence of extensively drug-resistant A. baumannii (XDRAB) infections has dramatically increased worldwide. In this study, we aimed to explore the complete genome sequence of… read more here.
Keywords: plasmid; baumannii ab329; resistance; aminoglycoside resistance ... See more keywords
Prevalence of high-level aminoglycoside resistance and genes encoding aminoglycoside-modifying enzymes in Enterococcus faecalis and Enterococcus faecium isolated in a university hospital in Tokyo.
Sign Up to like & getrecommendations! Published in 2020 at "Japanese journal of infectious diseases"
DOI: 10.7883/yoken.jjid.2019.416
Abstract: High-level aminoglycoside resistance (HLAR) limits treatment options for invasive enterococcal infections. We examined the prevalence of HLAR by disk diffusion method, carriage of genes for aminoglycoside-modifying enzymes by PCR, and production of β-lactamase by nitrocefin-based… read more here.
Keywords: high level; faecium; aminoglycoside resistance; level aminoglycoside ... See more keywords