Aminoguanidine pretreatment prevents methotrexate-induced small intestinal injury in the rat by attenuating nitrosative stress and restoring the activities of vital mitochondrial enzymes
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DOI: 10.1515/jbcpp-2016-0099
Abstract: Abstract Background: One of the major toxic side effects of methotrexate (MTX) is enterocolitis, for which there is no efficient standard treatment. Nitric oxide overproduction has been reported to play an important role in MTX-induced… read more here.
Keywords: aminoguanidine pretreatment; induced mucositis; mtx; mtx induced ... See more keywords