Reassessment of the threshold of the blood lead level to increase urinary δ‐aminolevulinic acid based on their relationship in recent lead workers in Japan
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Occupational Health"
DOI: 10.1002/1348-9585.12202
Abstract: Abstract Objectives The present study investigated the quantitative relationship between blood lead (Pb‐B) and urinary δ⁻aminolevulinic acid (ALA‐U) in lead workers, and examined the Pb‐B level that induces increases in ALA‐U and the corresponding ALA‐U.… read more here.
Keywords: aminolevulinic acid; increase; urinary aminolevulinic; blood lead ... See more keywords
5-Aminolevulinic Acid-Loaded Hyaluronic Acid Dissolving Microneedles for Effective Photodynamic Therapy of Superficial Tumors with Enhanced Long-Term Stability.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201900896
Abstract: 5-Aminolevulinic acid (5-ALA) is one of the most widely used prodrug in clinical photodynamic therapy of dermatological diseases and cancers; yet, its clinical application is still limited by the shallow skin penetration and unsatisfied stability… read more here.
Keywords: stability; photodynamic therapy; aminolevulinic acid; loaded hyaluronic ... See more keywords
Effective 5‐aminolevulinic acid production via T7 RNA polymerase and RuBisCO equipped Escherichia coli W3110
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28273
Abstract: Chromosome‐based engineering is a superior approach for gene integration generating a stable and robust chassis. Therefore, an effective amplifier, T7 RNA polymerase (T7RNAP) from bacteriophage, has been incorporated into Escherichia coli W3110 by site‐specific integration.… read more here.
Keywords: aminolevulinic acid; escherichia coli; rna polymerase; production ... See more keywords
Sodium ferrous citrate and 5‐aminolevulinic acid improve type 2 diabetes by maintaining muscle and mitochondrial health
Sign Up to like & getrecommendations! Published in 2023 at "Obesity"
DOI: 10.1002/oby.23705
Abstract: Improving mitochondrial function is a promising strategy for intervention in type 2 diabetes mellitus. This study investigated the preventive effects of sodium ferrous citrate (SFC) and 5‐aminolevulinic acid phosphate (ALA) on several metabolic dysfunctions associated… read more here.
Keywords: aminolevulinic acid; type diabetes; ferrous citrate; sodium ferrous ... See more keywords
Key transporters leading to specific protoporphyrin IX accumulation in cancer cell following administration of aminolevulinic acid in photodynamic therapy/diagnosis
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Clinical Oncology"
DOI: 10.1007/s10147-020-01766-y
Abstract: The administration of aminolevulinic acid allow the formation and accumulation of protoporphyrin IX specifically in cancer cells, which then lead to photocytotoxicity following light irradiation. This compound, when accumulated at high levels, could also be… read more here.
Keywords: accumulation; administration aminolevulinic; therapy; diagnosis ... See more keywords
5-aminolevulinic acid photodynamic therapy for the treatment of high-grade gliomas
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-019-03103-4
Abstract: IntroductionPhotodynamic therapy (PDT) is a two-step treatment involving the administration of a photosensitive agent followed by its activation at a specific light wavelength for targeting of tumor cells.Materials/MethodsA comprehensive review of the literature was performed to… read more here.
Keywords: high grade; aminolevulinic acid; treatment; pdt ... See more keywords
Economical synthesis of 14C-labeled aminolevulinic acid for specific in situ labeling of plant tetrapyrroles
Sign Up to like & getrecommendations! Published in 2019 at "Photosynthesis Research"
DOI: 10.1007/s11120-019-00654-5
Abstract: The application of metabolic radiolabeling techniques to plant tetrapyrroles, i.e., chlorophyll and hemes, is complicated by the difficulty of obtaining sufficient quantities of radiolabeled aminolevulinic acid (ALA). ALA, the first committed intermediate in the tetrapyrrole… read more here.
Keywords: aminolevulinic acid; 14c labeled; plant tetrapyrroles; economical synthesis ... See more keywords
Enhanced 5-Aminolevulinic Acid Production by Co-expression of Codon-Optimized hemA Gene with Chaperone in Genetic Engineered Escherichia coli
Sign Up to like & getrecommendations! Published in 2019 at "Applied Biochemistry and Biotechnology"
DOI: 10.1007/s12010-019-03178-9
Abstract: 5-Aminolevulinic acid (ALA) is an important metabolic intermediate compound with high value and has recently been used in agriculture and medicine. In this study, we have constructed six recombinant Escherichia coli (E. coli) strains that… read more here.
Keywords: codon optimized; production; escherichia coli; aminolevulinic acid ... See more keywords
Delta-Aminolevulinic Acid Dehydratase, Low Blood Lead Levels, Social Factors, and Intellectual Function in an Afro-Brazilian Children Community.
Sign Up to like & getrecommendations! Published in 2021 at "Biological trace element research"
DOI: 10.1007/s12011-021-02656-8
Abstract: Delta-aminolevulinic acid dehydratase (ALAD) enzyme catalyzes the second phase of the heme biosynthesis and is involved in lead toxicokinetics. This research aimed to evaluate its influence on the relationship between blood lead (PbB) levels and intellectual… read more here.
Keywords: aminolevulinic acid; delta aminolevulinic; acid dehydratase; blood ... See more keywords
5-Aminolevulinic acid fluorescence guided resection of malignant glioma: Hong Kong experience.
Sign Up to like & getrecommendations! Published in 2018 at "Asian journal of surgery"
DOI: 10.1016/j.asjsur.2017.06.004
Abstract: BACKGROUND 5-Aminolevulinic Acid (5-ALA) induced fluorescence is useful in guiding glioma resection. The extent of 5-ALA accumulation is beyond gadolinium contrast enhancement.1,2 Supratotal resection may be achieved, potentially granting patients with better survival. We present… read more here.
Keywords: glioma; malignant glioma; fluorescence; aminolevulinic acid ... See more keywords
Dynamics of absorption, metabolism, and excretion of 5-aminolevulinic acid in human intestinal Caco-2 cells
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2017.07.006
Abstract: 5-Aminolevulinic acid (ALA) is a precursor for the biosynthesis of porphyrins and heme. Although the oral administration of ALA has been widely applied in clinical settings, the dynamics of its absorption, metabolism, and excretion within… read more here.
Keywords: aminolevulinic acid; ala; caco cells; absorption metabolism ... See more keywords