Influence of 6-aminonicotinamide (6AN) on Leishmania promastigotes evaluated by metabolomics: Beyond the pentose phosphate pathway.
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DOI: 10.1016/j.cbi.2018.08.014
Abstract: 6-Aminonicotinamide (6AN) is an antimetabolite used to inhibit the NADPH-producing pentose phosphate pathway (PPP) in many cellular systems, making them more susceptible to oxidative stress. It is converted by a NAD(P)+ glycohydrolase to 6-aminoNAD and… read more here.
Keywords: phosphate pathway; pentose phosphate; leishmania promastigotes; aminonicotinamide 6an ... See more keywords