Distinct modulation of cellular immunopeptidome by the allosteric regulatory site of ER aminopeptidase 1.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202350449
Abstract: ER aminopeptidase 1 (ERAP1) is an ER-resident aminopeptidase that excises N-terminal residues of peptides that then bind onto Major Histocompatibility Complex I molecules (MHC-I) and indirectly modulates adaptive immune responses. ERAP1 contains an allosteric regulatory… read more here.
Keywords: distinct modulation; immunopeptidome; allosteric regulatory; regulatory site ... See more keywords
Discovery of potent and selective inhibitors of the Escherichia coli M1-aminopeptidase via multicomponent solid-phase synthesis of tetrazole-peptidomimetics.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.11.074
Abstract: The Escherichia coli neutral M1-aminopeptidase (ePepN) is a novel target identified for the development of antimicrobials. Here we describe a solid-phase multicomponent approach which enabled the discovery of potent ePepN inhibitors. The on-resin protocol, developed… read more here.
Keywords: potent selective; discovery potent; escherichia coli; aminopeptidase ... See more keywords
Production of aminopeptidase from soybean meal with nutrients supplementation by Bacillus licheniformis SWJS33: Feasibility and metabolic process
Sign Up to like & getrecommendations! Published in 2021 at "Lwt - Food Science and Technology"
DOI: 10.1016/j.lwt.2021.112392
Abstract: Abstract Enhancing aminopeptidase fermentation using cheap substrate is very necessary for industrial production and application of aminopeptidase. The suitability of using raw soybean meal (SBM) as substrate for aminopeptidase production by Bacillus licheniformis SWJS33 in… read more here.
Keywords: soybean meal; bacillus licheniformis; swjs33; process ... See more keywords
Can aminopeptidase N determined in the meconium be a candidate for biomarker of fetal intrauterine environment?
Sign Up to like & getrecommendations! Published in 2020 at "Experimental and molecular pathology"
DOI: 10.1016/j.yexmp.2020.104446
Abstract: AIM To investigate possible association of aminopeptidase N/CD13 with other parameters of possible homeostatic mechanisms in meconium for potential use in identifying intrauterine environmental stress factors during fetal and perinatal life. METHODS Aminopeptidase N/CD13 (APN/CD13),… read more here.
Keywords: aminopeptidase; apn cd13; candidate biomarker; cer ... See more keywords
Evaluation of the Hydrolysis Specificity of an Aminopeptidase from Bacillus licheniformis SWJS33 Using Synthetic Peptides and Soybean Protein Isolate.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.6b04426
Abstract: The substrate specificity of aminopeptidases has often been determined against aminoacyl-p-nitroanilide; thus, its specificity toward synthetic peptides and complex substrates remained unclear. The hydrolysis specificity of an aminopeptidase from Bacillus licheniformis SWJS33 (BLAM) was evaluated… read more here.
Keywords: aminopeptidase; hydrolysis specificity; hydrolysis; synthetic peptides ... See more keywords
Purification and Characterization of a Novel β-Cypermethrin-Degrading Aminopeptidase from Pseudomonas aeruginosa GF31.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.7b03288
Abstract: In this study, a novel β-cypermethrin-degrading enzyme was isolated and purified by 32.8 fold from the extracellular cell-free filtrate of Pseudomonas aeruginosa GF31with the protein recovery of 26.6%. The molecular mass of the enzyme was… read more here.
Keywords: pseudomonas aeruginosa; aminopeptidase; enzyme; cypermethrin degrading ... See more keywords
Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b00293
Abstract: ERAP1 is an endoplasmic reticulum-resident zinc aminopeptidase that plays an important role in the immune system by trimming peptides for loading onto major histocompatibility complex (MHC-I) proteins. Here we report discovery of the first inhibitors… read more here.
Keywords: discovery selective; endoplasmic reticulum; aminopeptidase; compound ... See more keywords
Hyperpolarized (1-13C)Alaninamide Is a Multifunctional In Vivo Sensor of Aminopeptidase N Activity, pH, and CO2.
Sign Up to like & getrecommendations! Published in 2022 at "ACS sensors"
DOI: 10.1021/acssensors.2c01203
Abstract: Spin hyperpolarization enables real-time metabolic imaging of carbon-13-labeled substrates. While hyperpolarized l-(1-13C)alaninamide is a probe of the cell-surface tumor marker aminopeptidase-N (APN, CD13), its activity in vivo has not been described. Scanning the kidneys of… read more here.
Keywords: vivo; hyperpolarized 13c; 13c alaninamide; activity ... See more keywords
Angiotensin II infusion enhances renal aminopeptidase expression in female but not male mice
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5734748
Abstract: Sexual dimorphism in the intrarenal homeostasis of angiotensin (Ang) peptides may influence blood pressure control. Aminopeptidase A (APA) and aminopeptidase N (APN) catalyse the degradation of AngII and AngIII, respectively, but sex differences in their… read more here.
Keywords: apa; expression; physiology; infusion ... See more keywords
Proline-specific aminopeptidase P prevents replication-associated genome instability
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1010025
Abstract: Genotoxic stress during DNA replication constitutes a serious threat to genome integrity and causes human diseases. Defects at different steps of DNA metabolism are known to induce replication stress, but the contribution of other aspects… read more here.
Keywords: associated genome; replication associated; prevents replication; genome instability ... See more keywords
Investigation of the proton relay system operative in human cystosolic aminopeptidase P
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0190816
Abstract: Aminopeptidase P, a metalloprotease, targets Xaa-Proline peptides for cleavage [1–4]. There are two forms of human AMPP, a membrane-bound form (hmAMPP) and a soluble cytosolic form (hcAMPP)[5]. Similar to the angiotensin-I-converting enzyme, AMPP plays an… read more here.
Keywords: relay system; guanidine; aminopeptidase; hcampp ... See more keywords