Diastereoselective synthesis of polyfluoroalkylated α-aminophosphonic acid derivatives
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Fluorine Chemistry"
DOI: 10.1016/j.jfluchem.2018.10.001
Abstract: Abstract The asymmetric synthesis of biorelevant aminophosphonates and aminophosphonic acids bearing trifluoromethyl, tetrafluoroethyl, perfluoropropyl or chlorodifluoromethyl group in the α-position to phosphonyl group is developed. Diastereoselective reduction of α-(poly)fluoroalkylated iminophosphonates, bearing stereodirecting α-phenylethyl group at… read more here.
Keywords: aminophosphonic acid; diastereoselective synthesis; group; synthesis polyfluoroalkylated ... See more keywords
Asymmetric Synthesis of Tetrasubstituted α-Aminophosphonic Acid Derivatives
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26113202
Abstract: Due to their structural similarity with natural α-amino acids, α-aminophosphonic acid derivatives are known biologically active molecules. In view of the relevance of tetrasubstituted carbons in nature and medicine and the strong dependence of the… read more here.
Keywords: aminophosphonic acid; tetrasubstituted aminophosphonic; synthesis tetrasubstituted; asymmetric synthesis ... See more keywords
Dipeptide analogues of fluorinated aminophosphonic acid sodium salts as moderate competitive inhibitors of cathepsin C
Sign Up to like & getrecommendations! Published in 2023 at "Beilstein Journal of Organic Chemistry"
DOI: 10.3762/bjoc.19.33
Abstract: In this paper, we present the solvolysis reaction of dipeptide analogues of fluorinated aminophosphonates with simultaneous quantitative deprotection of the amino group. To the best of our knowledge, this work is the first reported example… read more here.
Keywords: sodium salts; aminophosphonic acid; acid sodium; fluorinated aminophosphonic ... See more keywords