Straightforward Synthesis of 1‐Aryloxy‐1,1‐difluoro‐3‐aminopropan‐2‐ols – Accessing Fluorinated Derivatives of Commercialized Beta‐Blockers
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DOI: 10.1002/ejoc.202400568
Abstract: The efficient synthesis of an array of 1‐aryloxy‐1,1‐difluoro‐3‐aminopropan‐2‐ols in a one‐pot epoxidation/nucleophilic ring‐opening via the corresponding iodohydrines is described. This methodology permits the construction of 1,1‐difluorinated derivatives of commercialized beta‐blockers in addition to unprecedented members… read more here.
Keywords: derivatives commercialized; aryloxy difluoro; aminopropan ols; difluoro aminopropan ... See more keywords