Design and synthesis of fungal-selective resorcylate aminopyrazole Hsp90 inhibitors.
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DOI: 10.1021/acs.jmedchem.9b00826
Abstract: The molecular chaperone Hsp90, essential in all eukaryotes, plays a multifaceted role in promoting survival, virulence and drug resistance across diverse pathogenic fungal species. The chaperone is also critically important, however, to the pathogen's human… read more here.
Keywords: design synthesis; fungal selective; hsp90; hsp90 inhibitors ... See more keywords