Design, synthesis and evaluation of 4-aminoquinoline-purine hybrids as potential antiplasmodial agents.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.11.057
Abstract: A novel series of 4-aminoquinoline-purine hybrids were synthesized and assessed for their antiplasmodial activity against CQ-sensitive and CQ-resistant strains of P. falciparum. It was envisaged that linking of the 4-aminoquinoline pharmacophore (targeting heme-detoxification pathway of… read more here.
Keywords: design synthesis; purine hybrids; aminoquinoline purine; aminoquinoline ... See more keywords
N-Piperonyl substitution on aminoquinoline-pyrimidine hybrids: Effect on the antiplasmodial potency.
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DOI: 10.1016/j.ejmech.2017.03.007
Abstract: A series of 4-aminoquinoline-piperonyl-pyrimidine hybrids were synthesized with the aim of identifying compounds with enhanced antimalarial activity. All the synthesized molecules were evaluated in vitro against cultured Plasmodium falciparum W2 and D6 strains and exhibited potent… read more here.
Keywords: substitution aminoquinoline; aminoquinoline pyrimidine; aminoquinoline; piperonyl substitution ... See more keywords
Discovery of potent 4-aminoquinoline hydrazone inhibitors of NRH:quinoneoxidoreductase-2 (NQO2).
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.111649
Abstract: (NRH):quinone oxidoreductase 2 (NQO2) is associated with various processes involved in cancer initiation and progression probably via the production of ROS during quinone metabolism. Thus, there is a need to develop inhibitors of NQO2 that… read more here.
Keywords: discovery potent; inhibitors nqo2; aminoquinoline; hydrazone ... See more keywords
Accurate DFT studies on crystalline network formation of a new Co(II) complex bearing 8-aminoquinoline
Sign Up to like & getrecommendations! Published in 2018 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2017.12.033
Abstract: Abstract As a continuation of our studies on the coordination chemistry of 8-aminoquinoline (8-aq) and related nitrogen-containing heterocyclic ligands, we report the synthesis and crystal structure of a new complex of formula cis-[Co(8-aq)2(NCS)2] (1) by… read more here.
Keywords: dft; formation; aminoquinoline; crystalline network ... See more keywords
Copper-Catalyzed Base-Free N-Arylation of 8-Aminoquinoline Amides through Chelation Assistance
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DOI: 10.1055/s-0037-1610906
Abstract: A new and efficient approach for the N-arylation of 8-aminoquinoline amides with diaryliodonium salts has been developed. This chelation-assisted selective C–N cross-coupling reaction gave the desired N-arylated 8-aminoquinoline in moderate to good yields. In contrast… read more here.
Keywords: chelation; aminoquinoline amides; arylation aminoquinoline; aminoquinoline ... See more keywords
Synthesis, Molecular Docking, and Antimalarial Activity of Hybrid 4-Aminoquinoline-pyrano[2,3-c]pyrazole Derivatives
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DOI: 10.3390/ph14111174
Abstract: Widespread resistance of Plasmodium falciparum to current artemisinin-based combination therapies necessitate the discovery of new medicines. Pharmacophoric hybridization has become an alternative for drug resistance that lowers the risk of drug–drug adverse interactions. In this… read more here.
Keywords: docking antimalarial; aminoquinoline; strain; molecular docking ... See more keywords