Design, Synthesis, and Biological Evaluation of 2‐Aminothiazole Derivatives as Novel Checkpoint Kinase 1 (CHK1) Inhibitors
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DOI: 10.1002/cmdc.202200664
Abstract: A series of 2‐aminothiazole derivatives were designed, synthesized on the basis of bioisosterism strategy and evaluated for their CHK1 inhibitory activity. Most of them exhibited potent CHK1 inhibition, and excellent antiproliferative activity against MV‐4‐11 and… read more here.
Keywords: design synthesis; chk1; kinase; activity ... See more keywords
Discovery of aminothiazole derivatives as novel human enterovirus A71 capsid protein inhibitors.
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DOI: 10.1016/j.bioorg.2022.105683
Abstract: Enterovirus A71 (EV-A71), one of the major pathogens that causes hand, foot and mouth disease (HFMD), has seriously threatened the health and safety of young children. In this study, aminothiazole derivatives were synthesized and screened… read more here.
Keywords: aminothiazole derivatives; a71; enterovirus a71; a71 capsid ... See more keywords
Recent Developments and Biological Activities of 2-Aminothiazole Derivatives.
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DOI: 10.17344/acsi.2017.3547
Abstract: Aminothiazole nuclei and their various derivatives have been long used as precursors for the synthesis of biologically active molecules. As a typical heterocyclic amine, 2-aminothiazole is a cornerstone for the synthesis of many compounds, including… read more here.
Keywords: developments biological; biological activities; recent developments; activities aminothiazole ... See more keywords
Synthesis of Novel Aminothiazole Derivatives as Promising Antiviral, Antioxidant and Antibacterial Candidates
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DOI: 10.3390/ijms23147688
Abstract: It is well-known that thiazole derivatives are usually found in lead structures, which demonstrate a wide range of pharmacological effects. The aim of this research was to explore the antiviral, antioxidant, and antibacterial activities of… read more here.
Keywords: derivatives promising; antioxidant antibacterial; novel aminothiazole; activity ... See more keywords