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Amiodarone disrupts cholesterol biosynthesis pathway and causes accumulation of circulating desmosterol by inhibiting 24‐dehydrocholesterol reductase

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0 Published in 2020 at "Journal of Internal Medicine"

DOI: 10.1111/joim.13095

Abstract: We have earlier reported that amiodarone, a potent and commonly used antiarrhythmic drug increases serum desmosterol, the last precursor of cholesterol, in 20 cardiac patients by an unknown mechanism. read more here.

Keywords: biosynthesis pathway; desmosterol; amiodarone disrupts; pathway causes ... See more keywords