Development and Validation of a Novel Acute Myeloid Leukemia–Composite Model to Estimate Risks of Mortality
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2017.2714
Abstract: Importance To our knowledge, this multicenter analysis is the first to test and validate (1) the prognostic impact of comorbidities on 1-year mortality after initial therapy of acute myeloid leukemia (AML) and (2) a novel,… read more here.
Keywords: validation; year; mortality; composite model ... See more keywords
A nationwide survey of hypoplastic myelodysplastic syndrome (a multicenter retrospective study)
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Hematology"
DOI: 10.1002/ajh.24905
Abstract: Hypoplastic myelodysplastic syndrome (hMDS) is a distinct entity with bone marrow (BM) hypocellularity and the risk of death from BM failure (BMF). To elucidate the characteristics of hMDS, the data of 129 patients diagnosed between… read more here.
Keywords: risk; hmds; myelodysplastic syndrome; hypoplastic myelodysplastic ... See more keywords
Clinical characteristics and prognosis analysis of patients with de novo ASXL1-mutated AML treated with the C-HUNAN-AML-15 protocol: A multicenter study by the South China Pediatric AML Collaborative Group.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.6005
Abstract: BACKGROUND ASXL1 mutation is an independent prognostic factor in adult acute myeloid leukemia (AML), but its effect on the prognosis of pediatric AML is poorly understood. AIMS This study aimed to investigate the clinical characteristics… read more here.
Keywords: prognosis; aml; group; south china ... See more keywords
SOX4-induced upregulation of ARHGAP9 promotes the progression of acute myeloid leukemia.
Sign Up to like & getrecommendations! Published in 2021 at "Drug development research"
DOI: 10.1002/ddr.21837
Abstract: Acute myeloid leukemia (AML) is the most common acute leukemia. Rho GTPase activating protein 9 (ARHGAP9) has been reported to be positively correlated with overall survival of AML patients, but the specific molecular function remains… read more here.
Keywords: myeloid leukemia; arhgap9; acute myeloid; aml ... See more keywords
Preface to special issue: Acute myeloid leukemia—Genetics, stem cells, clonal evolution, and new therapies
Sign Up to like & getrecommendations! Published in 2019 at "Genes"
DOI: 10.1002/gcc.22800
Abstract: Therapeutic progress in acute myeloid leukemia (AML) has been frustratingly slow over the last four decades. The 5-year overall survival (OS) of AML patients younger than 60 years improved from around 20% in the 1980s… read more here.
Keywords: genetics; biology; acute myeloid; aml ... See more keywords
A novel HNRNPH1::ERG rearrangement in aggressive acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.1002/gcc.23051
Abstract: FUS::ERG rearrangement is a recurrent abnormality seen in a subgroup of acute myeloid leukemia (AML) with a poor prognosis. We described here a novel HNRNPH1::ERG rearrangement in a de novo AML. The patient was unresponsive… read more here.
Keywords: erg rearrangement; aml; fus erg; hnrnph1 erg ... See more keywords
Chemical exposures and risk of acute myeloid leukemia and myelodysplastic syndromes in a population‐based study
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Cancer"
DOI: 10.1002/ijc.30420
Abstract: Benzene exposure is one of the few well‐established risk factors for myeloid malignancy. Exposure to other chemicals has been inconsistently associated with hematologic malignancies. We evaluated occupational and residential chemical exposures as risk factors for… read more here.
Keywords: exposures risk; chemical exposures; population based; acute myeloid ... See more keywords
Knockdown of LncRNA‐UCA1 suppresses chemoresistance of pediatric AML by inhibiting glycolysis through the microRNA‐125a/hexokinase 2 pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26899
Abstract: Dysregulation of lncRNAs is implicated in chemoresistance in varieties of tumor including acute myeloid leukemia (AML). LncRNA urothelial carcinoma‐associated 1 (UCA1) was reported to play an oncogenic role in AML. However, whether UCA1 was involved… read more here.
Keywords: glycolysis; chemoresistance; adr; aml ... See more keywords
The prognostic value of matrix metalloproteinase‐7 and matrix metalloproteinase‐15 in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28351
Abstract: Matrix metalloproteinases (MMPs), a family of zinc‐dependent endopeptidases, are involved in a variety of physiological and pathological processes. We analyzed 11 data sets from Gene Expression Omnibus Database and found that MMP7 and MMP15 were… read more here.
Keywords: matrix metalloproteinase; matrix; mmp7 mmp15; acute myeloid ... See more keywords
Overexpression of miR‐216b: Prognostic and predictive value in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26171
Abstract: Accumulating studies have shown that miR‐216b acted as a tumor suppressor and was down‐regulated in solid tumors. However, little studies revealed the role or clinical implication of miR‐216b in blood cancers. Herein, we reported miR‐216b… read more here.
Keywords: overexpression; mir 216b; 216b expression; expression ... See more keywords
The Bcl‐2 inhibitor venetoclax inhibits Nrf2 antioxidant pathway activation induced by hypomethylating agents in AML
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28091
Abstract: Induction of reactive oxygen species (ROS), an important process for the cytotoxicity of various acute myeloid leukemia (AML) therapies including hypomethylating agents (HMAs), concurrently activates the NF‐E2‐related factor 2 (Nrf2) antioxidant response pathway which in… read more here.
Keywords: venetoclax; nrf2 antioxidant; treatment; hypomethylating agents ... See more keywords