Development and Validation of a Novel Acute Myeloid Leukemia–Composite Model to Estimate Risks of Mortality
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2017.2714
Abstract: Importance To our knowledge, this multicenter analysis is the first to test and validate (1) the prognostic impact of comorbidities on 1-year mortality after initial therapy of acute myeloid leukemia (AML) and (2) a novel,… read more here.
Keywords: validation; year; mortality; composite model ... See more keywords
A nationwide survey of hypoplastic myelodysplastic syndrome (a multicenter retrospective study)
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Hematology"
DOI: 10.1002/ajh.24905
Abstract: Hypoplastic myelodysplastic syndrome (hMDS) is a distinct entity with bone marrow (BM) hypocellularity and the risk of death from BM failure (BMF). To elucidate the characteristics of hMDS, the data of 129 patients diagnosed between… read more here.
Keywords: risk; hmds; myelodysplastic syndrome; hypoplastic myelodysplastic ... See more keywords
Clinico‐Genomic Interrogation of Secondary‐Type Acute Myeloid Leukemia: Response and Outcomes to Contemporary Therapies
Sign Up to like & getrecommendations! Published in 2025 at "American Journal of Hematology"
DOI: 10.1002/ajh.27628
Abstract: Ontogeny of acute myeloid leukemia (AML) provides prognostic information, however closer interrogation with respect to AML characteristics, genomics, and various treatments are warranted. We defined untreated clinical secondary (CS) AML as AML with a diagnosis… read more here.
Keywords: secondary type; acute myeloid; aml; lit venetoclax ... See more keywords
Clinical characteristics and prognosis analysis of patients with de novo ASXL1-mutated AML treated with the C-HUNAN-AML-15 protocol: A multicenter study by the South China Pediatric AML Collaborative Group.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.6005
Abstract: BACKGROUND ASXL1 mutation is an independent prognostic factor in adult acute myeloid leukemia (AML), but its effect on the prognosis of pediatric AML is poorly understood. AIMS This study aimed to investigate the clinical characteristics… read more here.
Keywords: prognosis; aml; group; south china ... See more keywords
Influence of genetic co‐mutation on chemotherapeutic outcome in NPM1‐mutated and FLT3‐ITD wild‐type AML patients
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Medicine"
DOI: 10.1002/cam4.70102
Abstract: Nucleophosmin 1 (NPM1) gene‐mutated acute myeloid leukemia (NPM1mut AML) is classified as a subtype with a favorable prognosis. However, some patients fail to achieve a complete remission or relapse after intensified chemotherapy. Genetic abnormalities in… read more here.
Keywords: influence genetic; genetic mutation; aml patients; mutation chemotherapeutic ... See more keywords
α‐Triazolylboronic Acids: A Novel Scaffold to Target FLT3 in AML
Sign Up to like & getrecommendations! Published in 2024 at "Chemmedchem"
DOI: 10.1002/cmdc.202400622
Abstract: The treatment of acute myeloid leukemia (AML) presents a challenge to current therapies because of the development of drug resistance. Genetic mutation of FMS‐like tyrosine kinase‐3 (FLT3) is a target of interest for AML treatment,… read more here.
Keywords: triazolylboronic acids; flt3; aml; acids novel ... See more keywords
SOX4-induced upregulation of ARHGAP9 promotes the progression of acute myeloid leukemia.
Sign Up to like & getrecommendations! Published in 2021 at "Drug development research"
DOI: 10.1002/ddr.21837
Abstract: Acute myeloid leukemia (AML) is the most common acute leukemia. Rho GTPase activating protein 9 (ARHGAP9) has been reported to be positively correlated with overall survival of AML patients, but the specific molecular function remains… read more here.
Keywords: myeloid leukemia; arhgap9; acute myeloid; aml ... See more keywords
Exosome‐Shuttled METTL14 From AML‐Derived Mesenchymal Stem Cells Promotes the Proliferation and Radioresistance in AML Cells by Stabilizing ROCK1 Expression via an m6A‐IGF2BP3‐Dependent Mechanism
Sign Up to like & getrecommendations! Published in 2024 at "Drug Development Research"
DOI: 10.1002/ddr.70025
Abstract: Acute myelogenous leukemia (AML)‐derived mesenchymal stem cells (MSCs) (AML‐MSCs) have been identified to play a significant role in AML progression. The functions of MSCs mainly depend on their paracrine action. Here, we investigated whether AML‐MSCs… read more here.
Keywords: m6a; aml; radioresistance; aml mscs ... See more keywords
Preface to special issue: Acute myeloid leukemia—Genetics, stem cells, clonal evolution, and new therapies
Sign Up to like & getrecommendations! Published in 2019 at "Genes"
DOI: 10.1002/gcc.22800
Abstract: Therapeutic progress in acute myeloid leukemia (AML) has been frustratingly slow over the last four decades. The 5-year overall survival (OS) of AML patients younger than 60 years improved from around 20% in the 1980s… read more here.
Keywords: genetics; biology; acute myeloid; aml ... See more keywords
A novel HNRNPH1::ERG rearrangement in aggressive acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.1002/gcc.23051
Abstract: FUS::ERG rearrangement is a recurrent abnormality seen in a subgroup of acute myeloid leukemia (AML) with a poor prognosis. We described here a novel HNRNPH1::ERG rearrangement in a de novo AML. The patient was unresponsive… read more here.
Keywords: erg rearrangement; aml; fus erg; hnrnph1 erg ... See more keywords
Chemical exposures and risk of acute myeloid leukemia and myelodysplastic syndromes in a population‐based study
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Cancer"
DOI: 10.1002/ijc.30420
Abstract: Benzene exposure is one of the few well‐established risk factors for myeloid malignancy. Exposure to other chemicals has been inconsistently associated with hematologic malignancies. We evaluated occupational and residential chemical exposures as risk factors for… read more here.
Keywords: exposures risk; chemical exposures; population based; acute myeloid ... See more keywords