Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine.
Sign Up to like & getrecommendations! Published in 2025 at "Molecular oncology"
DOI: 10.1002/1878-0261.70124
Abstract: Relapsed/refractory (R/R) disease is a major hurdle to long-term survival of acute myeloid leukemia (AML) patients treated with intensive cytarabine (AraC)-based chemotherapy. R/R AML salvage treatment with venetoclax (VEN) + azacitidine (AZA) results in overall response rates… read more here.
Keywords: cdk9; aml cell; arac; cell death ... See more keywords
Toll-like receptor 4 signaling pathway is correlated with pathophysiological characteristics of AML patients and its inhibition using TAK-242 suppresses AML cell proliferation.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.107202
Abstract: PURPOSE Acute myeloid leukemia (AML) is one of the most severe blood cancers. Many studies have revealed that inflammation has an essential role in the progression of hematopoietic malignancies. Since the toll-like receptor 4 (TLR4)… read more here.
Keywords: characteristics aml; tak 242; aml patients; pathophysiological characteristics ... See more keywords
Targeted Degradation of mRNA Decapping Enzyme DcpS by a VHL-Recruiting PROTAC.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00145
Abstract: The RNA decapping scavenger protein, DcpS, has recently been identified as a dependency in acute myeloid leukemia (AML). The potent DcpS inhibitor RG3039 attenuates AML cell viability, and shRNA knockdown of DcpS is also antiproliferative.… read more here.
Keywords: targeted degradation; dcps; aml cell; protac ... See more keywords
MALNC: a new mutant NPM1/IDH2R140 and PML-RARA-associated lncRNA with impact on AML cell proliferation, maturation and drug response
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Gene Therapy"
DOI: 10.1038/s41417-025-00954-0
Abstract: As the non-coding genome remains poorly characterized in acute myeloid leukemia (AML), we aimed to identify and functionally characterize novel long non-coding RNAs (lncRNAs) relevant to AML biology and treatment. We first identified lncRNAs overexpressed… read more here.
Keywords: idh2r140; cell proliferation; aml; aml cell ... See more keywords
CEBPA mutants down-regulate AML cell susceptibility to NK-mediated lysis by disruption of the expression of NKG2D ligands, which can be restored by LSD1 inhibition
Sign Up to like & getrecommendations! Published in 2022 at "Oncoimmunology"
DOI: 10.1080/2162402x.2021.2016158
Abstract: ABSTRACT NK group 2, member D (NKG2D) is one of the most critical activating receptors expressed by natural killer (NK) cells. There is growing evidence that acute myeloid leukemia (AML) cells may evade NK cell-mediated… read more here.
Keywords: cell; cebpa; aml cells; aml cell ... See more keywords
Abstract C042: Inhibition of Dihydroorotate Dehydrogenase (DHODH) by RP7214 attenuates growth and promotes differentiation of AML cell lines
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-19-c042
Abstract: Background: Dihydroorotate dehydrogenase (DHODH), a rate limiting enzyme in pyrimidine synthesis, is overexpressed in certain cancers; blockade of which impedes tumor cell proliferation via cell cycle arrest. RP7214 is a novel and potent DHODH inhibitor… read more here.
Keywords: aml cell; dihydroorotate dehydrogenase; cell; rp7214 ... See more keywords
Abstract 6825: Novel therapeutic strategies targeting MECOM rearranged AMLs discovered by unbiased drug screen
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-6825
Abstract: The MECOM locus at chromosome 3q26.2 encodes for the transcriptional regulator EVI1. In ∼10% of de novo AML, aberrant overexpression of EVI1 is observed. In approximately 50% of these it is due to inv(3)(q21;q26.2) or… read more here.
Keywords: drug screen; aml; 3q26 aml; unbiased drug ... See more keywords
Paics, a De Novo Purine Synthetic Enzyme, Is a Novel Target for AML Therapy
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-127047
Abstract: Progress has been made in deciphering molecular mechanisms underlying AML pathogenesis due in part to near-complete understanding of AML genomes. However, AML is yet a devastating disease with a long-term survival rate of less than… read more here.
Keywords: paicsi; cell lines; crispr cas9; aml ... See more keywords
Activin a Inhibition Impaired Human AML Cell Engraftment and Extended Survival in Immunodeficient Mice
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-208031
Abstract: Introduction: Myelodysplastic neoplasms (MDS) and myelofibrosis (MF) are clonal hematological disorders that affect multi-lineage blood cell production and develop into AML in approximately 30% and 20% of such patients, respectively (Menssen et al., 2020; Mannelli,… read more here.
Keywords: pre treated; aml; cell; aml cell ... See more keywords
CEBPG promotes acute myeloid leukemia progression by enhancing EIF4EBP1
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Cell International"
DOI: 10.1186/s12935-021-02305-z
Abstract: Background Acute myeloid leukemia (AML) is a myeloid neoplasm accounts for 7.6% of hematopoietic malignancies. AML is a complex disease, and understanding its pathophysiology is contributing to the improvement in the treatment and prognosis of… read more here.
Keywords: cebpg; progression; myeloid leukemia; acute myeloid ... See more keywords
miRNA-1 promotes acute myeloid leukemia cell pathogenesis through metabolic regulation
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2023.1192799
Abstract: Acute myeloid leukemia (AML) is a heterogeneous and deadly disease characterized by uncontrolled expansion of malignant blasts. Altered metabolism and dysregulated microRNA (miRNA) expression profiles are both characteristic of AML. However, there is a paucity… read more here.
Keywords: cell; aml cell; expression; acute myeloid ... See more keywords