AML with inv(16)/t(16;16) and high-risk cytogenetic abnormalities: atypical features and unfavorable outcome
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DOI: 10.1080/16078454.2022.2078027
Abstract: ABSTRACT Objectives Acute myeloid leukemia (AML) with inv(16)/t(16;16) is among the most frequent AML subtypes. It is recognized by the detection of the CBFB-MYH11 fusion which confers a favorable prognosis, irrespective of the presence of… read more here.
Keywords: cytogenetic abnormalities; risk; high risk; aml inv ... See more keywords
Molecular and Clinical Aspects of Acute Myeloid Leukemia with Inv(3)(q21q26)/t(3;3)(q21;q26) Carrying Spliceosomal Mutations
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DOI: 10.1182/blood-2020-139953
Abstract: Inversion or translocation of the chromosome 3, specifically inv(3)(q21q26.2/ t(3;3)(q21;q26.2) are present in 1-2% of acute myeloid leukemia (AML) cases and are classified as a distinct entity in the 2016 WHO classification. Hallmark genetic alterations… read more here.
Keywords: sf3b1 mutations; inv; aml inv; inv aml ... See more keywords