Treatment of relapsed AML and MDS after allogeneic stem cell transplantation with decitabine and DLI—a retrospective multicenter analysis on behalf of the German Cooperative Transplant Study Group
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DOI: 10.1007/s00277-017-3185-5
Abstract: In contrast to the evidence regarding azacitidine (Aza), there is limited knowledge about the combination of decitabine (DAC) and donor lymphocyte infusions as salvage therapy for relapse after allogeneic stem cell transplantation (allo-SCT) so far.… read more here.
Keywords: aml mds; dac; cell transplantation; decitabine ... See more keywords
Incidence, Risk Factors and Outcomes of Therapy-Related Myeloid Malignancies after Hematopoietic Cell Transplantation: Analysis of the Japan Society for Hematopoietic Cell Transplantation Late Complications and QOL Working Group
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DOI: 10.1016/j.bbmt.2019.12.179
Abstract: Background Therapy-related acute myeloid leukemia and myelodysplastic syndrome (t-AML/MDS) occur after hematopoietic cell transplantation (HCT). The incidence, risk factors and outcomes of t-AML/MDS among patients who underwent autologous or allogeneic HCT for a variety of… read more here.
Keywords: aml mds; cell transplantation; hematopoietic cell; transplantation ... See more keywords
Current status and trends in the diagnostics of AML and MDS.
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DOI: 10.1016/j.blre.2018.04.008
Abstract: Diagnostics of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) have recently been experiencing extensive modifications regarding the incorporation of next-generation sequencing (NGS) strategies into established diagnostic algorithms, classification and risk stratification systems, and minimal… read more here.
Keywords: aml mds; status trends; diagnostics aml; trends diagnostics ... See more keywords
Acute myeloid leukemia or myelodysplastic syndrome with chromosome 17 abnormalities and long-term outcomes with or without hematopoietic stem cell transplantation.
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DOI: 10.1016/j.leukres.2020.106402
Abstract: INTRODUCTION Chromosome 17 abnormalities, especially disorders of the 17p region and including TP53 gene mutations, result in very low rates of cure for patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) treated with… read more here.
Keywords: aml mds; chromosome abnormalities; myeloid leukemia; hct ... See more keywords
Epidemiology, management, and economic impact of acute myeloid leukemia and myelodysplastic syndrome in Spain at the hospital level: a claims database analysis
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DOI: 10.1080/13696998.2020.1840180
Abstract: Abstract Objectives This study reviewed patient characteristics, management, and medical costs of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDSs) in Spanish hospitals. Methods Data were extracted from the Spanish Ministry of Health records via… read more here.
Keywords: aml mds; myeloid leukemia; claims database; management ... See more keywords
Abstract CT085: iCare 1: A prospective clinical trial to predict treatment response based on mutanome-informed computational biology in patients with AML and MDS
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DOI: 10.1158/1538-7445.am2017-ct085
Abstract: Hypomethylating agents (HMAs) (azacitidine (aza), decitabine (dec)) and lenalidomide (len) are approved agents and used to treat patients with myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML). Despite their widespread use, HMAs fail in the… read more here.
Keywords: clinical trial; aml mds; response; patients aml ... See more keywords
Prognostic impact of circulating tumor DNA status post-allogeneic hematopoietic stem cell transplantation in AML and MDS.
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DOI: 10.1182/blood-2018-10-880690
Abstract: This study was performed to assess the utility of tumor-derived fragmentary DNA, or circulating tumor DNA (ctDNA), for identifying high-risk patients for relapse of acute myeloid leukemia and myelodysplastic syndrome (AML/MDS) after undergoing myeloablative allogeneic… read more here.
Keywords: aml mds; allogeneic hematopoietic; circulating tumor; tumor dna ... See more keywords
Using Social Media to Highlight Unmet Needs in Patients with AML and MDS Ineligible for Intensive Chemotherapy: A Patient Centered Perspective
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DOI: 10.1182/blood-2018-99-112922
Abstract: Objectives: For patients with AML/MDS who are ineligible for intensive chemotherapy, prognosis is poor and effective treatment options are limited, often leading to unmet medical needs in this population. A deeper understanding of the patient… read more here.
Keywords: chemotherapy; aml mds; information; patients caregivers ... See more keywords
The Lysine-Specific Demethylase 1 (LSD1) Inhibitor Tranylcypromine (TCP) in Combination with ATRA Is Tolerable and Has Anti-Leukemic Activity in Adult Patients with Relapsed/Refractory AML and MDS
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DOI: 10.1182/blood-2018-99-115411
Abstract: Introduction: Tranylcypromine (TCP) is an irreversible monoamine oxidase inhibitor, a potent antidepressant that has been in use since the 1960s. Additionally, TCP has been demonstrated to inhibit lysine-specific histone demethylase 1A (LSD1), which is highly… read more here.
Keywords: combination; aml mds; tcp; bid ... See more keywords
Durable Responses and Survival in High Risk AML and MDS Patients Treated with an Allogeneic Leukemia-Derived Dendritic Cell Vaccine
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DOI: 10.1182/blood-2019-127881
Abstract: Background. Maintenance of induced responses remains a significant unmet medical need in patients with acute myeloid leukemia (AML) or high risk myelodysplastic syndrome (MDS) not eligible for allogeneic hematopoietic stem cell transplantation (HSCT). The allogeneic… read more here.
Keywords: aml mds; risk; high risk; vaccination ... See more keywords
Low-Dose Decitabine Plus Venetoclax Maintenance Therapy Can Decrease the Relapse after Allogeneic Stem Cell Transplantation for MRD Positive High-Risk Acute Myeloid Leukemia and Myelodysplastic Syndrome
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DOI: 10.1182/blood-2020-140359
Abstract: Background: Acute myeloid leukemia (AML) and myelodysplasia (MDS) are usually associated with poor outcomes, especially in high-risk AML/MDS. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only curable option for patients suffering from high-risk AML/MDS.… read more here.
Keywords: aml mds; high risk; positive high; transplantation ... See more keywords