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   Articles with "aml patients" as a keyword



Microtransplantation in older patients with AML: A pilot study of safety, efficacy and immunologic effects

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recommendations! Published in 2020 at "American Journal of Hematology"

DOI: 10.1002/ajh.25781

Abstract: Older AML patients have low remission rates and poor survival outcomes with standard chemotherapy. Microtransplantation (MST) refers to infusion of allogeneic hematopoietic stem cells without substantial engraftment. MST has been shown to improve clinical outcomes… read more here.

Keywords: chemotherapy; microtransplantation; aml patients; mst ... See more keywords

Clinical implications of SRSF2 mutations in AML patients undergoing allogeneic stem cell transplantation

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recommendations! Published in 2021 at "American Journal of Hematology"

DOI: 10.1002/ajh.26298

Abstract: The SRSF2 mutations are frequently found in acute myeloid leukemia (AML) and mostly affect the P95 residue. Mutations in this splicing factor mediate abnormal splicing associated with exon skipping events, including EZH2 as a crucial… read more here.

Keywords: aml patients; hsct; clinical implications; implications srsf2 ... See more keywords

Immune‐relatedlncRNAs can predict the prognosis of acute myeloid leukemia

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recommendations! Published in 2021 at "Cancer Medicine"

DOI: 10.1002/cam4.4487

Abstract: The immune microenvironment in acute myeloid leukemia (AML) is closely related to patients’ prognosis. Long noncoding RNAs (lncRNAs) are emerging as key regulators in immune systems. In this study, we established a prognostic model using… read more here.

Keywords: irl signature; acute myeloid; aml patients; myeloid leukemia ... See more keywords

Influence of genetic co‐mutation on chemotherapeutic outcome in NPM1‐mutated and FLT3‐ITD wild‐type AML patients

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recommendations! Published in 2024 at "Cancer Medicine"

DOI: 10.1002/cam4.70102

Abstract: Nucleophosmin 1 (NPM1) gene‐mutated acute myeloid leukemia (NPM1mut AML) is classified as a subtype with a favorable prognosis. However, some patients fail to achieve a complete remission or relapse after intensified chemotherapy. Genetic abnormalities in… read more here.

Keywords: influence genetic; genetic mutation; aml patients; mutation chemotherapeutic ... See more keywords

Knockdown of let-7b in leukemia associated macrophages inhibit acute myeloid leukemia progression.

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recommendations! Published in 2022 at "Hematological oncology"

DOI: 10.1002/hon.3120

Abstract: Macrophages, critical components of bone marrow microenvironment, are reported to be remodeled into leukemia-associated macrophages (LAMs) in leukemic microenvironment where they contribute to leukemia development, characterized as M2 macrophages with pro-tumor effects. However, how leukemic… read more here.

Keywords: myeloid leukemia; leukemia associated; aml patients; leukemia ... See more keywords

Methylation‐associated DOK1 and DOK2 down‐regulation: Potential biomarkers for predicting adverse prognosis in acute myeloid leukemia

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recommendations! Published in 2018 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.26271

Abstract: DOK‐1 and DOK‐2 (DOK1/2) are closely related members of downstream of tyrosine kinase (DOK) family genes, which are found to be frequently rearranged in several hematopoietic cancers. However, the clinical implications of DOK1/2 in acute… read more here.

Keywords: methylation; dok1 expressions; aml patients; myeloid leukemia ... See more keywords
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Increased TIGIT expressing NK cells with dysfunctional phenotype in AML patients correlated with poor prognosis

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recommendations! Published in 2021 at "Cancer Immunology, Immunotherapy"

DOI: 10.1007/s00262-021-02978-5

Abstract: AML is the most common blood cancer in adults with a high relapse and an overall poor survival rate. NK cells have been demonstrated to have the capacity to eradicate AML blast, and an impaired… read more here.

Keywords: dysfunctional phenotype; aml patients; expressing cells; increased tigit ... See more keywords

Impact of pre-transplantation minimal residual disease determined by multiparameter flow cytometry on the outcome of AML patients with FLT3-ITD after allogeneic stem cell transplantation

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recommendations! Published in 2018 at "Annals of Hematology"

DOI: 10.1007/s00277-018-3265-1

Abstract: In this study, using multiparameter flow cytometry (FCM), we investigate the impact of minimal residual disease prior to transplantation (pre-MRD) on the transplant outcomes of AML patients with fms-related tyrosine kinase 3 (FLT3)-internal tandem duplication… read more here.

Keywords: aml patients; pre; group; pre fcm ... See more keywords
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dsDNA from extracellular vesicles (EVs) in adult AML

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recommendations! Published in 2020 at "Annals of Hematology"

DOI: 10.1007/s00277-020-04109-z

Abstract: Dear Editor, We read with great interest the article byKontopoulou et al. [1] describing the study of the dsDNA carried by extracellular vesicles (EVs) in pediatric acute myeloid leukemia (AML) patients. The authors described a… read more here.

Keywords: adult; aml patients; dna; genomic dna ... See more keywords

Precision medicine and novel molecular target therapies in acute myeloid leukemia: the background of hematologic malignancies (HM)-SCREEN-Japan 01

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recommendations! Published in 2019 at "International Journal of Clinical Oncology"

DOI: 10.1007/s10147-019-01467-1

Abstract: The development of allogeneic hematopoietic-stem-cell transplantation has improved the prognosis of younger acute myeloid leukemia (AML) patients. However, the outcome of older AML patients remains poor. The majority of AML patients are elderly. For elderly… read more here.

Keywords: medicine; gene mutations; aml patients; myeloid leukemia ... See more keywords

Study on the impact of CD4+ T cells and their subsets on relapse in AML patients during remission

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recommendations! Published in 2025 at "Clinical and Experimental Medicine"

DOI: 10.1007/s10238-025-01725-9

Abstract: This study investigates the impact of minimal residual disease (MRD) on relapse in patients with acute myeloid leukemia (AML), focusing on its interaction with immune cells function. A total of 49 AML patients were enrolled… read more here.

Keywords: aml patients; cd4 cells; mrd; impact cd4 ... See more keywords