Microtransplantation in older patients with AML: A pilot study of safety, efficacy and immunologic effects
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DOI: 10.1002/ajh.25781
Abstract: Older AML patients have low remission rates and poor survival outcomes with standard chemotherapy. Microtransplantation (MST) refers to infusion of allogeneic hematopoietic stem cells without substantial engraftment. MST has been shown to improve clinical outcomes… read more here.
Keywords: chemotherapy; microtransplantation; aml patients; mst ... See more keywords
Clinical implications of SRSF2 mutations in AML patients undergoing allogeneic stem cell transplantation
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DOI: 10.1002/ajh.26298
Abstract: The SRSF2 mutations are frequently found in acute myeloid leukemia (AML) and mostly affect the P95 residue. Mutations in this splicing factor mediate abnormal splicing associated with exon skipping events, including EZH2 as a crucial… read more here.
Keywords: aml patients; hsct; clinical implications; implications srsf2 ... See more keywords
Immune‐relatedlncRNAs can predict the prognosis of acute myeloid leukemia
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DOI: 10.1002/cam4.4487
Abstract: The immune microenvironment in acute myeloid leukemia (AML) is closely related to patients’ prognosis. Long noncoding RNAs (lncRNAs) are emerging as key regulators in immune systems. In this study, we established a prognostic model using… read more here.
Keywords: irl signature; acute myeloid; aml patients; myeloid leukemia ... See more keywords
Knockdown of let-7b in leukemia associated macrophages inhibit acute myeloid leukemia progression.
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DOI: 10.1002/hon.3120
Abstract: Macrophages, critical components of bone marrow microenvironment, are reported to be remodeled into leukemia-associated macrophages (LAMs) in leukemic microenvironment where they contribute to leukemia development, characterized as M2 macrophages with pro-tumor effects. However, how leukemic… read more here.
Keywords: myeloid leukemia; leukemia associated; aml patients; leukemia ... See more keywords
Methylation‐associated DOK1 and DOK2 down‐regulation: Potential biomarkers for predicting adverse prognosis in acute myeloid leukemia
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DOI: 10.1002/jcp.26271
Abstract: DOK‐1 and DOK‐2 (DOK1/2) are closely related members of downstream of tyrosine kinase (DOK) family genes, which are found to be frequently rearranged in several hematopoietic cancers. However, the clinical implications of DOK1/2 in acute… read more here.
Keywords: methylation; dok1 expressions; aml patients; myeloid leukemia ... See more keywords
Increased TIGIT expressing NK cells with dysfunctional phenotype in AML patients correlated with poor prognosis
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DOI: 10.1007/s00262-021-02978-5
Abstract: AML is the most common blood cancer in adults with a high relapse and an overall poor survival rate. NK cells have been demonstrated to have the capacity to eradicate AML blast, and an impaired… read more here.
Keywords: dysfunctional phenotype; aml patients; expressing cells; increased tigit ... See more keywords
Impact of pre-transplantation minimal residual disease determined by multiparameter flow cytometry on the outcome of AML patients with FLT3-ITD after allogeneic stem cell transplantation
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Hematology"
DOI: 10.1007/s00277-018-3265-1
Abstract: In this study, using multiparameter flow cytometry (FCM), we investigate the impact of minimal residual disease prior to transplantation (pre-MRD) on the transplant outcomes of AML patients with fms-related tyrosine kinase 3 (FLT3)-internal tandem duplication… read more here.
Keywords: aml patients; pre; group; pre fcm ... See more keywords
dsDNA from extracellular vesicles (EVs) in adult AML
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DOI: 10.1007/s00277-020-04109-z
Abstract: Dear Editor, We read with great interest the article byKontopoulou et al. [1] describing the study of the dsDNA carried by extracellular vesicles (EVs) in pediatric acute myeloid leukemia (AML) patients. The authors described a… read more here.
Keywords: adult; aml patients; dna; genomic dna ... See more keywords
Precision medicine and novel molecular target therapies in acute myeloid leukemia: the background of hematologic malignancies (HM)-SCREEN-Japan 01
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DOI: 10.1007/s10147-019-01467-1
Abstract: The development of allogeneic hematopoietic-stem-cell transplantation has improved the prognosis of younger acute myeloid leukemia (AML) patients. However, the outcome of older AML patients remains poor. The majority of AML patients are elderly. For elderly… read more here.
Keywords: medicine; gene mutations; aml patients; myeloid leukemia ... See more keywords
Prognostic Significance of Complex Karyotypes in Acute Myeloid Leukemia
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DOI: 10.1007/s11864-019-0612-y
Abstract: Opinion statementAcute myeloid leukemia (AML) patients with a complex karyotype (CK-AML) show at least 3 unrelated clonal cytogenetic abnormalities with notoriously poor outcome. Such cases fall into either AML with myelodysplasia-related changes or therapy-related AML… read more here.
Keywords: complex karyotypes; significance complex; aml patients; myeloid leukemia ... See more keywords
Distinct prognostic values of Annexin family members expression in acute myeloid leukemia
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DOI: 10.1007/s12094-019-02045-7
Abstract: BackgroundAnnexin family consist of 12 members, many of them are frequently dysregulated in human cancers. However, the diagnosis and prognosis of Annexin family expression in acute myeloid leukemia (AML) remain elusive. The aim of the… read more here.
Keywords: aml patients; pediatric aml; family members; annexin family ... See more keywords