Impact of AML1/ETO Fusion on the Efficacy of Venetoclax Plus Hypomethylating Agents in Newly Diagnosed Acute Myeloid Leukemia
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DOI: 10.1007/s11523-024-01039-y
Abstract: AML1/ETO fusion confers favorable prognosis in acute myeloid leukemia (AML) treated with intensive chemotherapy (IC). However, the impact of AML1/ETO fusion on the efficacy of venetoclax in the treatment of AML is unclear. The aim… read more here.
Keywords: eto fusion; efficacy venetoclax; aml; aml1 eto ... See more keywords
Targeting miR‐193a‐AML1‐ETO‐β‐catenin axis by melatonin suppresses the self‐renewal of leukaemia stem cells in leukaemia with t (8;21) translocation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14399
Abstract: Abstract AML1‐ETO, the most common fusion oncoprotein by t (8;21) in acute myeloid leukaemia (AML), enhances hematopoietic self‐renewal and leukemogenesis. However, currently no specific therapies have been reported for t (8;21) AML patients as AML1‐ETO… read more here.
Keywords: aml1 eto; eto; mir 193a; self renewal ... See more keywords
The Three E Proteins Define a Heterogeneity of the AML1-ETO-Containing Transcription Factor Complex (AETFC) and Differentially Regulate t(8;21) Leukemogenesis
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DOI: 10.1182/blood-2018-99-112372
Abstract: The leukemogenic AML1-ETO fusion protein is produced by the t(8;21) translocation, which is one of the most common chromosomal abnormalities in acute myeloid leukemia (AML). In leukemic cells, AML1-ETO resides in and functions through a… read more here.
Keywords: aml1 eto; three proteins; eto; leukemogenesis ... See more keywords
Venetoclax-based regimens are non-inferior to chemotherapy in core binding factor AML, including AML1-ETO
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DOI: 10.1182/blood-2025-6965
Abstract: Background Core binding factor acute myeloid leukemia (CBF-AML) is a favorable-risk molecular subtype defined by the presence of either AML1-ETO (RUNX1::RUNX1T1) or CBFβ-MYH11 (CBFB::MYH11) fusion transcripts. While standard “7+3” induction chemotherapy remains the first-line treatment,… read more here.
Keywords: aml1 eto; based regimens; eto; chemotherapy ... See more keywords
Inhibition of the mutated c-KIT kinase in AML1-ETO-positive leukemia cells restores sensitivity to PARP inhibitor.
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DOI: 10.1182/bloodadvances.2019000756
Abstract: c-KIT activating mutations cause resistance to PARP inhibitor in AML1-ETO–positive leukemias. c-KIT inhibitor avapritinib downregulates BRCA1/2 and DNA-PK catalytic subunit to restore the sensitivity to PARP inhibitor. read more here.
Keywords: aml1 eto; inhibitor; eto positive; sensitivity parp ... See more keywords
A novel epigenetic AML1‐ETO/THAP10/miR‐383 mini‐circuitry contributes to t(8;21) leukaemogenesis
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DOI: 10.15252/emmm.201607180
Abstract: DNA methylation patterns are frequently deregulated in t(8;21) acute myeloid leukaemia (AML), but little is known of the mechanisms by which specific gene sets become aberrantly methylated. Here, we found that the promoter DNA methylation… read more here.
Keywords: thap10; eto thap10; aml1 eto; mir 383 ... See more keywords
AML1-ETO-Related Fusion Circular RNAs Contribute to the Proliferation of Leukemia Cells
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DOI: 10.3390/ijms24010071
Abstract: The AML1-ETO (RUNX1-RUNX1T1) fusion gene created by the chromosome translocation t(8;21) (q21;q22) is one of the essential contributors to leukemogenesis. Only a few studies in the literature have focused on fusion gene-derived circular RNAs (f-circRNAs).… read more here.
Keywords: fusion; proliferation; circular rnas; aml1 eto ... See more keywords
Amyloid precursor protein has clinical and prognostic significance in AML1-ETO-positive acute myeloid leukemia
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DOI: 10.3892/ol.2017.7396
Abstract: Amyloid precursor protein (APP) has been reported to be highly expressed in acute myeloid leukemia (AML)1-eight-twenty one (ETO)-positive AML. In the present study, the clinical and prognostic significance of APP expression was assessed in 65… read more here.
Keywords: aml1 eto; eto positive; precursor protein; amyloid precursor ... See more keywords
Gene mutation profile and risk stratification in AML1-ETO-positive acute myeloid leukemia based on next-generation sequencing
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DOI: 10.3892/or.2019.7375
Abstract: Gene mutations play an important role in the development and progression of AML1-ETO-positive acute myeloid leukemia (AE-AML). Nevertheless, the gene mutation profile in this subtype of leukemia remains unclear. In addition, the clinical and prognostic… read more here.
Keywords: aml1 eto; eto positive; positive acute; gene ... See more keywords
A Case of AML1-ETO Positive Acute Myeloid Leukemia Morphologically Similar to Chronic Myelogenous Leukemia.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical laboratory"
DOI: 10.7754/clin.lab.2022.220914
Abstract: BACKGROUND The goal was to study the role of the morphology, immunophenotype, karyotype and fusion gene expression in a patient with diagnosis of AML1-ETO positive acute myeloid leukemia. METHODS A case of AML1-ETO positive acute… read more here.
Keywords: myeloid leukemia; leukemia; expression; aml1 eto ... See more keywords
Clinical Characteristics and Diagnosis of Children t(8; 21)/AML1-ETO Positive Acute Myeloid Leukemia with Basophilic Granulocytosis.
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DOI: 10.7754/clin.lab.2025.250407
Abstract: BACKGROUND The goal was to investigate the clinical features and diagnostic methods of children with t(8;21)/ AML1-ETO positive acute myeloid leukemia with basophilic granulocytosis. METHODS The clinical features and diagnostic methods of a case of… read more here.
Keywords: aml1 eto; acute myeloid; leukemia; positive acute ... See more keywords