Pharmacokinetics and Bioequivalence Evaluation of 2 Olmesartan Medoxomil and Amlodipine Besylate Fixed‐Dose Combination Tablets in Healthy Chinese Volunteers Under Fasting and Fed Conditions
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DOI: 10.1002/cpdd.1086
Abstract: Combined antihypertensive drugs have become the basic method of treating hypertension. Olmesartan and amlodipine, as representative drugs of angiotensin receptor blockers and calcium channel blockers, were developed as a compound formulation for antihypertensive treatment. The… read more here.
Keywords: time; fasting fed; fed conditions; bioequivalence ... See more keywords
Pharmacokinetic Comparison of a Fixed-Dose Combination of Candesartan Cilexetil/Amlodipine/Atorvastatin Versus Co-administration of Individual Formulations in Healthy Participants
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DOI: 10.1007/s12325-024-02869-y
Abstract: Fixed-dose combinations (FDCs) of angiotensin II receptor blockers, calcium channel blockers, and statins are conventional therapeutic interventions prescribed for cardiovascular diseases. This study aimed at drawing a comparison between the pharmacokinetics and safety of an… read more here.
Keywords: candesartan cilexetil; cilexetil amlodipine; individual formulations; amlodipine atorvastatin ... See more keywords
Development of a chemometric-assisted spectrophotometric method for quantitative simultaneous determination of Amlodipine and Valsartan in commercial tablet
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DOI: 10.1016/j.ijleo.2020.165110
Abstract: Abstract In this study, two drugs named Amlodipine (AML) and Valsartan (VAL) related to the high blood pressure were simultaneously determined in synthetic mixtures and Valzomix tablet. For this purpose, the chemometric-assisted spectrophotometric method was… read more here.
Keywords: assisted spectrophotometric; method; spectrophotometric method; chemometric assisted ... See more keywords
Application of an LC–MS/MS method for the analysis of amlodipine, valsartan and hydrochlorothiazide in polypill for a bioequivalence study
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DOI: 10.1016/j.jpha.2017.06.001
Abstract: A sensitive and selective method has been proposed for the simultaneous determination of amlodipine (AML), valsartan (VAL) and hydrochlorothiazide (HCTZ) in human plasma by liquid chromatography–tandem mass spectrometry (LC–MS/MS). The analytes and their deuterated analogs… read more here.
Keywords: valsartan; val; method; hctz ... See more keywords
An anchored simulated treatment comparison of uptitration of amlodipine compared with a low-dose combination treatment with amlodipine 5 mg/bisoprolol 5 mg for patients with hypertension suboptimally controlled by amlodipine 5 mg monotherapy
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DOI: 10.1080/03007995.2022.2030112
Abstract: Abstract Objective To compare changes in systolic and diastolic blood pressures (SBP, DBP) from baseline to following 8 weeks of treatment with a low dose combination of amlodipine 5 mg plus bisoprolol 5 mg versus up titration to… read more here.
Keywords: combination; comparison; dose combination; amlodipine ... See more keywords
Vasodilation in patients with calcium channel blocker poisoning treated with high-dose insulin: a comparison of amlodipine versus non-dihydropyridines
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DOI: 10.1080/15563650.2022.2131565
Abstract: Abstract Background: High dose insulin (HDI), an inotrope and vasodilator, is a standard therapy for calcium channel blocker (CCB) poisoning. HDI causes vasodilation by stimulating endothelial nitric oxide synthase (eNOS). Most literature supporting HDI for… read more here.
Keywords: non; vasodilation; amlodipine; dose insulin ... See more keywords
Attempted self-castration with bilateral intratesticular injections of calcium chloride.
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DOI: 10.1080/15563650.2023.2200895
Abstract: ide (methylene blue), and extracorporeal membrane oxygenation. The total number of amlodipine cases managed by the Illinois Poison Center each year was compared to the number of amlodipine-related deaths, and proportional trends were compared to… read more here.
Keywords: calcium; calcium channel; amlodipine; chloride ... See more keywords
Quantitative analysis of two pharmaceutical combinations containing amlodipine with either bisoprolol or candesartan using different UV spectrophotometric methods.
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DOI: 10.1093/jaoacint/qsac018
Abstract: BACKGROUND Two fixed-dose combination tablets of amlodipine with bisoprolol and amlodipine with candesartan were recently approved for the treatment of hypertension. OBJECTIVE Three UV spectrophotometric analytical methods were developed for the estimation of the above… read more here.
Keywords: candesartan; method; bisoprolol; amlodipine ... See more keywords
[LB.01.33] DRUG ADHERENCE AND CLINICAL OUTCOME IN RESPONSE TO PERINDOPRIL/AMLODIPINE FIXED DOSE COMBINATION IN AN ITALIAN CLINICAL PRACTICE SETTING. THE AMLODIPINE-PERINDOPRIL IN REAL SETTINGS (AMPERES) STUDY
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DOI: 10.1097/01.hjh.0000523463.74674.b2
Abstract: Objective: The purpose of this study was to assess in real practice the effect on adherence of a switch from a single- or two-pills therapy (SPT/FC) of perindopril and/or amlodipine to fixed-dose combination (FDC) of… read more here.
Keywords: adherence; amlodipine; dose combination; perindopril amlodipine ... See more keywords
Cancer Risk of Angiotensin II Receptor Blocker Valsartan: A Population-based Study
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DOI: 10.1097/fjc.0000000000001217
Abstract: Supplemental Digital Content is Available in the Text. Abstract: Nitrosamine contamination of generic valsartan was found in 2018. This study aimed to investigate whether long-term use of valsartan increases cancer risk. Patients prescribed valsartan or… read more here.
Keywords: valsartan; incidence; risk; cancer risk ... See more keywords
Severe non-cardiogenic pulmonary edema following low-dose amlodipine ingestion: a case report
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DOI: 10.1097/ms9.0000000000003891
Abstract: Introduction and Importance: Amlodipine, a dihydropyridine calcium channel blocker, is widely used for hypertension. While peripheral edema is common, non-cardiogenic pulmonary edema (NCPE) is rare and typically linked to overdose. This case reports severe NCPE… read more here.
Keywords: low dose; edema; non cardiogenic; case ... See more keywords