Hydroxylamine as an ammonia equivalent: access to NH-tetrahydroisoquinolonic derivatives from aldoximes by the Castagnoli–Cushman reaction followed by reduction
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DOI: 10.1016/j.mencom.2019.05.033
Abstract: A novel synthetic protocol towards trans-NH-tetrahydroisoquinolonic acid esters is based on the Castagnoli–Cushman reaction between aromatic aldehyde oximes and homophthalic anhydride, followed by esterification and TiCl3-promoted reduction. The scope of the method with respect to… read more here.
Keywords: cushman reaction; ammonia equivalent; reduction; hydroxylamine ammonia ... See more keywords