Identification and Characterization of an Efficient Phenylalanine Ammonia-Lyase from Photorhabdus luminescens
Sign Up to like & getrecommendations! Published in 2021 at "Applied Biochemistry and Biotechnology"
DOI: 10.1007/s12010-020-03477-6
Abstract: A putative aromatic amino acid ammonia-lyase gene (named Pl-pal) was discovered in Photorhabdus luminescens DSM 3368. BLAST and phylogenetic analyses predicted that this enzyme is a histidine ammonia-lyase, whereas sequence alignment suggested that it is… read more here.
Keywords: photorhabdus luminescens; phenylalanine ammonia; ammonia lyase; ammonia ... See more keywords
Substituted phosphonic analogues of phenylglycine as inhibitors of phenylalanine ammonia lyase from potatoes.
Sign Up to like & getrecommendations! Published in 2018 at "Biochimie"
DOI: 10.1016/j.biochi.2018.06.005
Abstract: A series of phosphonic acid analogues of phenylglycine variously substituted in phenyl ring have been synthesized and evaluated for their inhibitory activity towards potato l-phenylalanine ammonia lyase. Most of the compounds appeared to act as… read more here.
Keywords: analogues phenylglycine; site; phenylalanine ammonia; substituted phosphonic ... See more keywords
Cloning, characterization and expression of a phenylalanine ammonia-lyase gene (CcPAL) from cumin (Cuminum cyminum L.)
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Applied Research on Medicinal and Aromatic Plants"
DOI: 10.1016/j.jarmap.2020.100253
Abstract: Abstract Phenylalanine ammonia-lyase (PAL) that functions a substantial role in defense mechanisms, growth, and development of the plant, is situated at branching point from primary to secondary metabolism. In this study, using highly conserved sequences… read more here.
Keywords: cumin cuminum; cuminum cyminum; phenylalanine ammonia; gene ... See more keywords
Preformulation studies with phenylalanine ammonia lyase: essential prelude to a microcapsule formulation for the management of phenylketonuria.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2022.03.016
Abstract: Phenylalanine ammonia lyase (PAL) metabolizes phenylalanine to transcinnamic acid (TCA). Our eventual goal is to develop a PAL microcapsule formulation to deplete phenylalanine in the gastrointestinal tract (g.i.t). The focus of this research is pre-formulation… read more here.
Keywords: formulation; ammonia lyase; phenylalanine ammonia; microcapsule formulation ... See more keywords
Phenylalanine ammonia lyase (PAL): From discovery to enzyme substitution therapy for phenylketonuria.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular genetics and metabolism"
DOI: 10.1016/j.ymgme.2018.06.002
Abstract: Phenylketonuria (PKU) is a genetic inborn error in metabolism that impacts many people globally, with profound individual and societal consequences when left untreated. The journey of phenylalanine ammonia lyase (PAL) from plant enzyme to enzyme… read more here.
Keywords: enzyme substitution; lyase pal; enzyme; phenylalanine ammonia ... See more keywords
Deuterium Kinetic Isotope Effects Resolve Low-Temperature Substrate Radical Reaction Pathways and Steps in B12-Dependent Ethanolamine Ammonia-Lyase.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00588
Abstract: The first-order reaction kinetics of the cryotrapped 1,1,2,2-2H4-aminoethanol substrate radical intermediate state in the adenosylcobalamin (B12)-dependent ethanolamine ammonia-lyase (EAL) from Salmonella enterica serovar Typhimurium are measured over the range of 203-225 K by using time-resolved,… read more here.
Keywords: substrate radical; reaction; b12 dependent; ethanolamine ammonia ... See more keywords
Zymophore identification enables the discovery of novel phenylalanine ammonia lyase enzymes
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13990-0
Abstract: The suite of biological catalysts found in Nature has the potential to contribute immensely to scientific advancements, ranging from industrial biotechnology to innovations in bioenergy and medical intervention. The endeavour to obtain a catalyst of… read more here.
Keywords: identification; phenylalanine ammonia; ammonia lyase;
Formulation and PEGylation optimization of the therapeutic PEGylated phenylalanine ammonia lyase for the treatment of phenylketonuria
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0173269
Abstract: Phenylketonuria (PKU) is a genetic metabolic disease in which the decrease or loss of phenylalanine hydroxylase (PAH) activity results in elevated, neurotoxic levels of phenylalanine (Phe). Due to many obstacles, PAH enzyme replacement therapy is… read more here.
Keywords: treatment; pal; phenylalanine ammonia; ravpal peg ... See more keywords
Changes in phenols composition and activity of phenylalanine-ammonia lyase in apples after fungal infections
Sign Up to like & getrecommendations! Published in 2018 at "Horticultural Science"
DOI: 10.17221/42/2010-hortsci
Abstract: Schovankova J., Opatova H., 2011. Changes in phenols composition and activity of phenylalanine-ammonia lyase in apples after fungal infections. Hort. Sci. (Prague), 38: 1–10. Th e defensive reaction of apple cultivar Idared (Malus domestica Borkh.)… read more here.
Keywords: activity phenylalanine; phenylalanine ammonia; ammonia lyase;
Phylogenomic analysis of phenylalanine ammonia-lyase (PAL) multigene family and their differential expression analysis in wheat (Triticum aestivum L.) suggested their roles during different stress responses
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.982457
Abstract: Phenylalanine ammonia-lyase (PAL) is a key enzyme in the phenylalanine metabolism pathway and plays an important role in plant growth and stress response. It has been widely reported in plants, but less studied in wheat.… read more here.
Keywords: wheat; phenylalanine ammonia; expression; analysis ... See more keywords
Molecular identification of phenylalanine ammonia lyase-encoding genes EfPALs and EfPAL2-interacting transcription factors in Euryale ferox
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2023.1114345
Abstract: Flavonoids are one of the most important secondary metabolites in plants, and phenylalanine ammonia-lyase (PAL) is the first rate-limiting enzyme for their biosynthesis. However, detailed information on the regulation of PAL in plants is still… read more here.
Keywords: biosynthesis; transcription factors; phenylalanine ammonia; efpal2 ... See more keywords