Analysis of the Destabilization of Bacterial Membranes by Quaternary Ammonium Compounds: A Combined Experimental and Computational Study
Sign Up to like & getrecommendations! Published in 2019 at "ChemBioChem"
DOI: 10.1002/cbic.201900698
Abstract: The mechanism of action of quaternary ammonium compound (QAC) antiseptics has long been assumed to be straightforward membrane disruption, although the process of approaching and entering the membrane has little modeling precedent. Furthermore, questions have… read more here.
Keywords: analysis; destabilization; ammonium compounds; ammonium ... See more keywords
Bushy‐Tailed QACs: The Development of Multicationic Quaternary Ammonium Compounds with a High Degree of Alkyl Chain Substitution
Sign Up to like & getrecommendations! Published in 2024 at "ChemMedChem"
DOI: 10.1002/cmdc.202400301
Abstract: Quaternary ammonium compounds have served as a first line of protection for human health as surface disinfectants and sanitizers for nearly a century. However, increasing levels of bacterial resistance have spurred the development of novel… read more here.
Keywords: alkyl; ammonium compounds; quaternary ammonium; bushy tailed ... See more keywords
Phytotoxicity and oxidative effects of typical quaternary ammonium compounds on wheat (Triticum aestivum L.) seedlings
Sign Up to like & getrecommendations! Published in 2019 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-019-05822-7
Abstract: The large-scale use of quaternary ammonium compounds (QACs) in medicines or disinfectants can lead to their release into the environment, posing a potential risk to organisms. This study examined the effects of three typical QACs,… read more here.
Keywords: quaternary ammonium; phytotoxicity oxidative; ammonium compounds; wheat seedlings ... See more keywords
Toxicity of Quaternary Ammonium Compounds (QACs) as single compounds and mixtures to aquatic non-target microorganisms: Experimental data and predictive models.
Sign Up to like & getrecommendations! Published in 2017 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2017.04.028
Abstract: The toxic effects of five Quaternary Ammonium Compounds (QACs) that are widely used as active ingredients in personal care products were assessed using the bioluminescent bacterium Aliivibrio fischeri (formerly Vibrio fischeri) (Microtox® test system). The… read more here.
Keywords: compounds qacs; toxicity quaternary; ammonium compounds; ammonium ... See more keywords
Quaternary Ammonium Compounds: A Chemical Class of Emerging Concern
Sign Up to like & getrecommendations! Published in 2023 at "Environmental Science & Technology"
DOI: 10.1021/acs.est.2c08244
Abstract: Quaternary ammonium compounds (QACs), a large class of chemicals that includes high production volume substances, have been used for decades as antimicrobials, preservatives, and antistatic agents and for other functions in cleaning, disinfecting, personal care… read more here.
Keywords: care products; quaternary ammonium; personal care; ammonium compounds ... See more keywords
Occurrence and Distribution of Antibacterial Quaternary Ammonium Compounds in Chinese Estuaries Revealed by Machine Learning-Assisted Mass Spectrometric Analysis.
Sign Up to like & getrecommendations! Published in 2024 at "Environmental science & technology"
DOI: 10.1021/acs.est.4c02380
Abstract: Antimicrobial resistance (AMR) undermines the United Nations Sustainable Development Goals of good health and well-being. Antibiotics are known to exacerbate AMR, but nonantibiotic antimicrobials, such as quaternary ammonium compounds (QACs), are now emerging as another… read more here.
Keywords: analysis; machine learning; quaternary ammonium; qacs ... See more keywords
Chiral Discrimination of Varied Ammonium Compounds through 1H NMR Using a Binuclear Ti Complex Sensor.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.9b04373
Abstract: A simple chiral binuclear titanium complex ((S)-Ti2L3Na4) was first prepared and served as an excellent chiral sensor for discriminating a variety of chiral ammoniums by 1H NMR. In the presence of trifluoroacetic acid, the in-situ-generated… read more here.
Keywords: varied ammonium; compounds nmr; ammonium compounds; chiral discrimination ... See more keywords
From Antibacterial to Antibiofilm Targeting: An Emerging Paradigm Shift in the Development of Quaternary Ammonium Compounds (QACs).
Sign Up to like & getrecommendations! Published in 2023 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.2c00469
Abstract: In a previous development stage, mostly individual antibacterial activity was a target in the optimization of biologically active compounds and antiseptic agents. Although this targeting is still valuable, a new trend has appeared since the… read more here.
Keywords: development; quaternary ammonium; paradigm shift; ammonium compounds ... See more keywords
Ethene-1,1,2,2-tetracarbonitrile and Methanol in the Methylating Reaction of Tertiary Amines to the Quaternary Ammonium Compounds of 1,1-Dicyano-2-methoxy-2-oxoethane-1-ide
Sign Up to like & getrecommendations! Published in 2018 at "Synlett"
DOI: 10.1055/s-0037-1610343
Abstract: We discovered a new method to methylate tertiary amines such as urotropine, triethylamine, pyridine, 2-methylpyridine, 4-acetylpyridine, and isonicotinamide, up to quaternary ammonium compounds, with 1,1-dicyano-2-methoxy-2-oxoethane-1-ide being the counterion. Methyl-1,3,5,7-tetraazaadamantan-1-ium 1,1-dicyano-2-methoxy-2-oxoethane-1-ide, N,N-diethyl-N-methylethanaminium 1,1-dicyano-2-methoxy-2-oxoethane-1-ide, and substituted-methylpyridinium 1,1-dicyano-2-methoxy-2-oxoethane-1-ides… read more here.
Keywords: tertiary amines; dicyano methoxy; methoxy oxoethane; ammonium compounds ... See more keywords
Quaternary ammonium compounds in roots and leaves of Capparis spinosa L. from Saudi Arabia and Italy: investigation by HPLC-MS and 1H NMR
Sign Up to like & getrecommendations! Published in 2019 at "Natural Product Research"
DOI: 10.1080/14786419.2018.1475376
Abstract: Abstract Capparis spinosa L. is a perennial plant typical of the Mediterranean flora and a multipurpose plant used for curing various human ailments. Quaternary ammonium compounds (QACs), as constituents of Capparaceae, play important roles in… read more here.
Keywords: quaternary ammonium; saudi arabia; ammonium compounds; capparis spinosa ... See more keywords
Reproductive & developmental toxicity of quaternary ammonium compounds
Sign Up to like & getrecommendations! Published in 2024 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioae107
Abstract: Abstract Quaternary ammonium compounds are a class of chemicals commonly used as disinfectants in household and healthcare settings. Their usage has significantly increased in recent years due to the COVID-19 pandemic. In addition, quaternary ammonium… read more here.
Keywords: reproductive developmental; ammonium compound; ammonium; quaternary ammonium ... See more keywords