Enantioselective α-Chlorination Reactions of in Situ Generated C1 Ammonium Enolates under Base-Free Conditions
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DOI: 10.1021/acs.orglett.1c02256
Abstract: The asymmetric α-chlorination of activated aryl acetic acid esters can be carried out with high levels of enantioselectivities utilizing commercially available isothiourea catalysts under base-free conditions. The reaction, which proceeds via the in situ formation… read more here.
Keywords: free conditions; base free; enantioselective chlorination; ammonium enolates ... See more keywords
Catalytic enantioselective synthesis of 1,4-dihydropyridines via the addition of C(1)-ammonium enolates to pyridinium salts
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DOI: 10.1039/d1sc03860e
Abstract: The regio- and stereoselective addition of C(1)-ammonium enolates – generated in situ from aryl esters and the isothiourea catalyst (R)-BTM – to pyridinium salts bearing an electron withdrawing substituent in the 3-position allows the synthesis… read more here.
Keywords: pyridinium salts; ammonium enolates; addition; addition ammonium ... See more keywords