Human amnion epithelial cells for the prevention of bronchopulmonary dysplasia: a phase 1 dose escalation study
Sign Up to like & getrecommendations! Published in 2019 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2019.03.403
Abstract: Background & Aim Background: Advances in neonatal intensive care have been associated with improved survival of preterm infants. But along with survival, the morbidity bronchopulmonary dysplasia (BPD), the chronic lung disease of prematurity, is also… read more here.
Keywords: human amnion; amnion epithelial; risk; bronchopulmonary dysplasia ... See more keywords
Dexamethasone induces primary amnion epithelial cell senescence through telomere-P21 associated pathway†
Sign Up to like & getrecommendations! Published in 2019 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioz048
Abstract: Abstract Dexamethasone (Dex), a corticosteroid hormone, is used during the perinatal period to help fetal lung and other organ development. Conversely, Dex-induced cell proliferation has been associated with accelerated aging. Using primary amnion epithelial cells… read more here.
Keywords: primary amnion; dex; senescence; amnion epithelial ... See more keywords
Serelaxin enhances the therapeutic effects of human amnion epithelial cell‐derived exosomes in experimental models of lung disease
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14666
Abstract: There is growing interest in stem cell‐derived exosomes for their therapeutic and regenerative benefits given their manufacturing and regulatory advantages over cell‐based therapies. As existing fibrosis impedes the viability and efficacy of stem cell/exosome‐based strategies… read more here.
Keywords: epithelial cell; cell derived; amnion epithelial; cell ... See more keywords
Effect of Human Amnion Epithelial Cells on the Acute Inflammatory Response in Fetal Sheep
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DOI: 10.3389/fphys.2017.00871
Abstract: Intra-amniotic (IA) lipopolysaccharide (LPS) injection in sheep induces inflammation in the fetus. Human amnion epithelial cells (hAECs) moderate the effect of IA LPS on fetal development, but their influence on the acute inflammatory response to… read more here.
Keywords: epithelial cells; acute inflammatory; response; inflammatory response ... See more keywords
Amnion Epithelial Cells Promote Lung Repair via Lipoxin A4
Sign Up to like & getrecommendations! Published in 2017 at "Stem Cells Translational Medicine"
DOI: 10.5966/sctm.2016-0077
Abstract: Human amnion epithelial cells (hAECs) have been shown to possess potent immunomodulatory properties across a number of disease models. Recently, we reported that hAECs influence macrophage polarization and activity, and that this step was dependent… read more here.
Keywords: medicine; epithelial cells; amnion epithelial; macrophage ... See more keywords