Scale‐Up of Human Amniotic Epithelial Cells Through Regulation of Epithelial‐Mesenchymal Plasticity Under Defined Conditions (Adv. Sci. 11/2025)
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DOI: 10.1002/advs.202570071
Abstract: Human Amniotic Epithelial Cells Human amniotic epithelial cells (hAECs) originate from the amniotic ectoderm. The proliferation of hAECs during the embryonic development is related to their epithelial mesenchymal plasticity (EMP) properties, which is lost in… read more here.
Keywords: mesenchymal plasticity; amniotic epithelial; epithelial mesenchymal; human amniotic ... See more keywords
The potential role of multifunctional human amniotic epithelial cells in pancreatic islet transplantation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.3214
Abstract: Pancreatic islet cell transplantation has proven efficacy as a treatment for type 1 diabetes mellitus, chiefly in individuals who are refractory to conventional insulin replacement therapy. At present its clinical use is restricted, firstly by… read more here.
Keywords: pancreatic islet; epithelial cells; amniotic epithelial; islet ... See more keywords
Amniotic Epithelial Cell Culture.
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DOI: 10.1007/978-1-4939-8600-2_7
Abstract: Ovine amniotic epithelial cells (oAEC) are a subset of placental stem cells with great regenerative and immunomodulatory properties. Indeed, oAEC are object of intense study for regenerative medicine thanks to the several advantages in developing… read more here.
Keywords: medicine; epithelial cell; amniotic epithelial; cell culture ... See more keywords
Isolation and biological characteristics of sheep amniotic epithelial cells
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DOI: 10.1007/s10616-019-00299-1
Abstract: Amniotic epithelial cells (AECs), isolated from placenta, have epithelial cells and stem cells characteristics. Most of the previous studies focused on the biological characteristics of human amniotic epithelial cells, which demonstrated amniotic epithelial cells not… read more here.
Keywords: epithelial cells; amniotic epithelial; sheep amniotic; characteristics sheep ... See more keywords
Insulin-producing organoids engineered from islet and amniotic epithelial cells to treat diabetes
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DOI: 10.1038/s41467-019-12472-3
Abstract: Maintaining long-term euglycemia after intraportal islet transplantation is hampered by the considerable islet loss in the peri-transplant period attributed to inflammation, ischemia and poor angiogenesis. Here, we show that viable and functional islet organoids can… read more here.
Keywords: epithelial cells; amniotic epithelial; treat; islet ... See more keywords
Progesterone prevents epithelial-mesenchymal transition of ovine amniotic epithelial cells and enhances their immunomodulatory properties
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DOI: 10.1038/s41598-017-03908-1
Abstract: The in vitro expansion is detrimental to therapeutic applications of amniotic epithelial cells (AEC), an emerging source of fetal stem cells. This study provides molecular evidences of progesterone (P4) role in preventing epithelial-mesenchymal transition (EMT)… read more here.
Keywords: epithelial cells; amniotic epithelial; mesenchymal transition; epithelial mesenchymal ... See more keywords
Human Amniotic Epithelial Cell Transplantation is Safe and Well Tolerated in Patients with Compensated Cirrhosis: A First-in-Human Trial
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DOI: 10.1093/stcltm/szae023
Abstract: Abstract Placenta-derived human amniotic epithelial cells (hAEC) exhibit anti-inflammatory and anti-fibrotic effects in cirrhosis models. We conducted a first-in-human phase I clinical trial to assess the safety and tolerability of hAEC in adults with compensated… read more here.
Keywords: cirrhosis; trial; infusion; amniotic epithelial ... See more keywords
Combination therapy with human amniotic epithelial cells and hyaluronic acid promotes immune balance recovery in type 1 diabetic rats through local engraftment
Sign Up to like & getrecommendations! Published in 2022 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.13246
Abstract: Stem cell engraftment is currently a promising approach for type 1 diabetes mellitus (T1DM) treatment. In our previous study, engraftment of a combination of human amniotic epithelial cells (hAECs) and hyaluronic acid (HA) showed potent… read more here.
Keywords: amniotic epithelial; hyaluronic acid; human amniotic; local engraftment ... See more keywords
Amniotic Epithelial Cells Accelerate Diabetic Wound Healing by Modulating Inflammation and Promoting Neovascularization
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DOI: 10.1155/2018/1082076
Abstract: Human amniotic epithelial cells (hAECs) are nontumorigenic, highly abundant, and low immunogenic and possess multipotent differentiation ability, which make them become ideal alternative stem cell source for regenerative medicine. Previous studies have demonstrated the therapeutic… read more here.
Keywords: wound healing; amniotic epithelial; epithelial cells; inflammation ... See more keywords
In Vivo Model of Osteoarthritis to Compare Allogenic Amniotic Epithelial Stem Cells and Autologous Adipose Derived Cells
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DOI: 10.3390/biology11050681
Abstract: Simple Summary An early resolution of osteoarthritis (OA), through minimally invasive orthobiological solutions, would be important to enable a return to daily and sport activities, and delay prosthesis solutions. No study has yet evaluated amniotic… read more here.
Keywords: amniotic epithelial; osteoarthritis; adipose derived; stem cells ... See more keywords
DNA Microarray-Based Global Gene Expression Profiling in Human Amniotic Epithelial Cells Predicts the Potential of Microalgae-Derived Squalene for the Nervous System and Metabolic Health
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DOI: 10.3390/biomedicines10010048
Abstract: In recent years, perinatal stem cells, such as human amniotic epithelial cells (hAECs), have attracted increasing interest as a novel tool of stem cell-based high-throughput drug screening. In the present study, we investigated the bioactivities… read more here.
Keywords: analysis; system; human amniotic; amniotic epithelial ... See more keywords