Scaffold Hopping from Amodiaquine to Novel Nurr1 Agonist Chemotypes via Microscale Analogue Libraries
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DOI: 10.1002/cmdc.202200026
Abstract: Several lines of evidence suggest the ligand‐sensing transcription factor Nurr1 as a promising target to treat neurodegenerative diseases. Nurr1 modulators to validate and exploit this therapeutic potential are rare, however. To identify novel Nurr1 agonist… read more here.
Keywords: agonist chemotypes; nurr1 agonist; novel nurr1; microscale analogue ... See more keywords
Pharmacokinetic profile of amodiaquine and its active metabolite desethylamodiaquine in Ghanaian patients with uncomplicated falciparum malaria
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DOI: 10.1186/s12936-020-03553-6
Abstract: Background Accurate measurement of anti-malarial drug concentrations in therapeutic efficacy studies is essential to distinguish between inadequate drug exposure and anti-malarial drug resistance, and to inform optimal anti-malarial dosing in key target population groups. Methods… read more here.
Keywords: metabolite desethylamodiaquine; active metabolite; amodiaquine active; amodiaquine ... See more keywords
Methylene Blue-Based Combination Therapy with Amodiaquine Prevents Severe Malaria in an Experimental Rodent Model
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DOI: 10.3390/pharmaceutics14102031
Abstract: Untreated malaria can progress rapidly to severe forms ( read more here.
Keywords: based combination; methylene blue; combination; cerebral malaria ... See more keywords