Dissolution Behavior of Weakly Basic Pharmaceuticals from Amorphous Dispersions Stabilized by a Poly(dimethylaminoethyl Methacrylate) Copolymer.
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DOI: 10.1021/acs.molpharmaceut.2c00456
Abstract: Amorphous solid dispersions (ASDs) are a well-documented formulation approach to improve the rate and extent of dissolution for hydrophobic pharmaceuticals. However, weakly basic compounds can complicate standard approaches to ASDs due to pH-dependent solubility, resulting… read more here.
Keywords: eudragit epo; dissolution behavior; amorphous dispersions; dissolution ... See more keywords