Dissolution Behavior of Weakly Basic Pharmaceuticals from Amorphous Dispersions Stabilized by a Poly(dimethylaminoethyl Methacrylate) Copolymer.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00456
Abstract: Amorphous solid dispersions (ASDs) are a well-documented formulation approach to improve the rate and extent of dissolution for hydrophobic pharmaceuticals. However, weakly basic compounds can complicate standard approaches to ASDs due to pH-dependent solubility, resulting… read more here.
Keywords: eudragit epo; dissolution behavior; amorphous dispersions; dissolution ... See more keywords
Soluplus Stabilized Amorphous Dispersions for Enhanced Oral Absorption of Felodipine.
Sign Up to like & getrecommendations! Published in 2025 at "Current drug delivery"
DOI: 10.2174/0115672018363757241216061705
Abstract: BACKGROUND Overcoming the poor aqueous solubility of small-molecule drugs is a major challenge in developing clinical pharmaceuticals. Felodipine (FLDP), an L-type calcium calcium channel blocker, is a poorly water-soluble drug. OBJECTIVES The study aimed to… read more here.
Keywords: soluplus stabilized; fldp ssas; drug; amorphous dispersions ... See more keywords