The Need for Restructuring the Disordered Science of Amorphous Drug Formulations
Sign Up to like & getrecommendations! Published in 2017 at "Pharmaceutical Research"
DOI: 10.1007/s11095-017-2174-7
Abstract: The alarming numbers of poorly soluble discovery compounds have centered the efforts towards finding strategies to improve the solubility. One of the attractive approaches to enhance solubility is via amorphization despite the stability issue associated… read more here.
Keywords: research; amorphous based; amorphous formulation; formulation ... See more keywords
Millifluidic synthesis of amorphous drug‐polysaccharide nanoparticle complex with tunable size intended for supersaturating drug delivery applications
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2016.11.030
Abstract: Graphical abstract Figure. No caption available. HighlightsTunable nanoplex size is obtained by controlling residence time in millifluidics.Millifluidics enabled production of much smaller nanoplex than bulk mixing.Nanoplex formation in millifluidics favored acidic pH, LMW CHI, and… read more here.
Keywords: drug; size; amorphous drug; millifluidic synthesis ... See more keywords
Co‐former selection for co‐amorphous drug‐amino acid formulations
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.12.036
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT We have previously developed a fast screening method on the ability of twenty amino acids (AA) to form co‐amorphous formulations with six drugs upon ball milling. In this… read more here.
Keywords: amino; amorphous formulations; amorphous drug; stability ... See more keywords
Comparative Assessment of Miniaturized Screening Approaches for Selection of Polymers for Amorphous Drug Stabilization.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2017.11.006
Abstract: The present work highlights the use of miniaturized approaches to screen and prioritize development of solid dispersions that provide stabilization of the amorphous drug against crystallization and enhanced dissolution over the crystalline form. The approaches… read more here.
Keywords: stabilization; screening approaches; drug; fasted state ... See more keywords
Comparisons of in Vitro Models to Evaluate the Membrane Permeability of Amorphous Drug Nanoparticles.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00565
Abstract: The spontaneous formation of amorphous drug nanoparticles following the release of a drug from a supersaturating formulation is gaining increasing attention due to their potential contribution to increased oral bioavailability. The formation of nanosized drug… read more here.
Keywords: drug particles; drug nanoparticles; amorphous drug; permeability ... See more keywords
Effect of Polymer Chain Length on the Physical Stability of Amorphous Drug-Polymer Blends at Ambient Pressure.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.8b00312
Abstract: Rational selection of polymers for amorphous drug stabilization is necessary for further successful development of solid dispersion technology. In this paper, we investigate the effect of polymer chain length on the inhibition of amorphous drug… read more here.
Keywords: polymer; drug; amorphous drug; spectroscopy ... See more keywords
Co-Amorphous Drug Formulations in Numbers: Recent Advances in Co-Amorphous Drug Formulations with Focus on Co-Formability, Molar Ratio, Preparation Methods, Physical Stability, In Vitro and In Vivo Performance, and New Formulation Strategies
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics13030389
Abstract: Co-amorphous drug delivery systems (CAMS) are characterized by the combination of two or more (initially crystalline) low molecular weight components that form a homogeneous single-phase amorphous system. Over the past decades, CAMS have been widely… read more here.
Keywords: drug; drug formulations; amorphous drug; performance ... See more keywords
Benchmarking the Solubility Enhancement and Storage Stability of Amorphous Drug–Polyelectrolyte Nanoplex against Co-Amorphous Formulation of the Same Drug
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DOI: 10.3390/pharmaceutics14050979
Abstract: Amorphization, typically in the form of amorphous solid dispersion (ASD), represents a well-established solubility enhancement strategy for poorly soluble drugs. Recently, two amorphous drug formulations, i.e., the amorphous drug–polyelectrolyte nanoparticle complex (nanoplex) and co-amorphous system,… read more here.
Keywords: nanoplex amorphous; drug polyelectrolyte; amorphous drug; stability ... See more keywords
Mechanism for Stabilizing an Amorphous Drug Using Amino Acids within Co-Amorphous Blends
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15020337
Abstract: Designing co-amorphous formulations is now recognized as a relevant strategy for improving the bioavailability of low-molecular-weight drugs. In order to determine the most suitable low-molecular-weight excipients for stabilizing the drug in the amorphous state, screening… read more here.
Keywords: amorphous state; amino acids; using amino; amorphous drug ... See more keywords