Dual Functionality of Bile Acid: Physical Stabilization of Drugs in the Amorphous Form and Solubility Enhancement in Solution.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00294
Abstract: Drugs containing an amino aromatic nitrogen moiety were stabilized in the amorphous form by the surfactant cholic acid (CA). Coamorphous systems of lamotrigine (LAM), pyrimethamine (PYR), and trimethoprim (TRI) were each prepared with CA. Drug-CA… read more here.
Keywords: solubility; coamorphous systems; amorphous form; drug ... See more keywords
Elucidating the mechanism of nucleation inhibition of pathology crystallization of gout based on the evidence from amorphous form and in solution
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra03289a
Abstract: The first gout attack in a hyperuricaemic patient may be regarded as a nucleation event which is caused by monosodium urate monohydrate (MSUM) deposition in the synovial fluid. The effect of Tailor-Made Inhibition (TMI) may… read more here.
Keywords: inhibition; nucleation; amorphous form; pathology ... See more keywords
Relative bioavailability of ertugliflozin tablets containing the amorphous form versus tablets containing the cocrystal form
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Clinical Pharmacology and Therapeutics"
DOI: 10.5414/cp204212
Abstract: Objectives: Ertugliflozin is a selective sodium-glucose cotransporter 2 inhibitor approved for the treatment of type 2 diabetes in adults. In its natural form, ertugliflozin exists as an amorphous solid with physicochemical properties that prevent commercial… read more here.
Keywords: tablets containing; bioavailability ertugliflozin; relative bioavailability; form ... See more keywords