LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "amorphous solid" as a keyword



Hot Melted Amorphous Solid Dispersion of Ritonavir With PVPVA and Span 60: Physicochemical Characterization and In Vitro Assessment

Sign Up to like & get
recommendations! Published in 2025 at "Polymers for Advanced Technologies"

DOI: 10.1002/pat.70301

Abstract: The therapeutic activity of ritonavir (RTV), an antiretroviral drug, is limited due to its poor aqueous solubility and permeability. Amorphous solid dispersion (ASD) by the hot melt technique emerges as an outstanding approach for the… read more here.

Keywords: amorphous solid; solid dispersion; ritonavir; drug ... See more keywords

Anomalous release of indoles from amorphous solid dispersion formed with a polymeric network

Sign Up to like & get
recommendations! Published in 2024 at "Journal of Thermal Analysis and Calorimetry"

DOI: 10.1007/s10973-024-13648-w

Abstract: Amorphous solid dispersion (ASDs) is a technique used in the pharmaceutical industry to enhance the solubility, dissolution rate, and bioavailability of poorly soluble drugs. Polymeric materials, and recently polymer gels form and stabilize the amorphous… read more here.

Keywords: spectroscopy; release; amorphous solid; solid dispersion ... See more keywords

Influence of Low-Molecular-Weight Excipients on the Phase Behavior of PVPVA64 Amorphous Solid Dispersions

Sign Up to like & get
recommendations! Published in 2017 at "Pharmaceutical Research"

DOI: 10.1007/s11095-017-2316-y

Abstract: PurposeThe oral bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs) can be improved by the preparation of amorphous solid dispersions (ASDs) where the API is dissolved in polymeric excipients. Desired properties of such ASDs like… read more here.

Keywords: low molecular; solid dispersions; molecular weight; amorphous solid ... See more keywords

Development of Fast-Dissolving Amorphous Solid Dispersion of Itraconazole by Melt Extrusion of its Mixture with Weak Organic Carboxylic Acid and Polymer

Sign Up to like & get
recommendations! Published in 2018 at "Pharmaceutical Research"

DOI: 10.1007/s11095-018-2407-4

Abstract: PurposeThe purpose of this study was to explore the feasibility of developing amorphous solid dispersion (ASD) by inducing acid-base interaction at an elevated temperature using hot melt extrusion.MethodsItraconazole and glutaric acid, which do not form salt… read more here.

Keywords: melt extrusion; solid dispersion; itraconazole; amorphous solid ... See more keywords

Examination of dissolution ratio of β-carotene in water for practical application of β-carotene amorphous solid dispersion

Sign Up to like & get
recommendations! Published in 2021 at "Journal of Food Science and Technology"

DOI: 10.1007/s13197-021-04991-z

Abstract: β-Carotene (BC) has an antioxidant effect that removes active oxygen in vivo and can reduce the risk of developing various diseases, but it is almost insoluble in water. Therefore, to develop highly effective BC functional… read more here.

Keywords: amorphous solid; water; carotene; dissolution ratio ... See more keywords
Photo from wikipedia

A novel amorphous solid dispersion based on drug-polymer complexation.

Sign Up to like & get
recommendations! Published in 2020 at "Drug delivery and translational research"

DOI: 10.1007/s13346-020-00869-3

Abstract: Rafoxanide (RAF) is a poorly water-soluble drug that forms a complex with povidone K25 (PVP) in a cosolvent system containing acetone and an alkaline aqueous medium. This study aims to investigate the impact of RAF-PVP… read more here.

Keywords: raf; drug polymer; complexation; drug ... See more keywords

Cellulose based polymers in development of amorphous solid dispersions

Sign Up to like & get
recommendations! Published in 2019 at "Asian Journal of Pharmaceutical Sciences"

DOI: 10.1016/j.ajps.2018.09.003

Abstract: Cellulose derivatives have gained immense popularity as stabilizers for amorphous solid dispersion owing to their diverse physicochemical properties. More than 20 amorphous solid dispersion-based products that have been approved for marketing consist of cellulose derivatives… read more here.

Keywords: solid dispersion; solid dispersions; cellulose derivatives; cellulose based ... See more keywords

Interfacial interaction track of amorphous solid dispersions established by water‐soluble polymer and indometacin

Sign Up to like & get
recommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"

DOI: 10.1016/j.ejps.2017.05.067

Abstract: Abstract The present work studied interfacial interactions of amorphous solid dispersions matrix of indometacin (IMC) that established using PVP K30 (PVP) and PEG 6000 (PEG) by focusing on their interaction forces and wetting process. Infrared… read more here.

Keywords: contact angle; water; solid dispersions; amorphous solid ... See more keywords

Amorphous solid dispersion of cyclosporine A prepared with fine droplet drying process: Physicochemical and pharmacokinetic characterization.

Sign Up to like & get
recommendations! Published in 2017 at "International journal of pharmaceutics"

DOI: 10.1016/j.ijpharm.2017.01.018

Abstract: The present study aimed to develop an amorphous solid dispersion (ASD) of cyclosporine A (CsA) by a fine droplet drying (FDD) process for improvement in oral absorption of CsA. CsA and hydroxypropyl cellulose-SSL were dissolved… read more here.

Keywords: droplet drying; solid dispersion; amorphous solid; asd csa ... See more keywords

Building a better particle: Leveraging physicochemical understanding of amorphous solid dispersions and a hierarchical particle approach for improved delivery at high drug loadings

Sign Up to like & get
recommendations! Published in 2019 at "International Journal of Pharmaceutics"

DOI: 10.1016/j.ijpharm.2019.01.009

Abstract: &NA; Amorphous solid dispersions are a promising option for managing compounds with poor aqueous solubility. However, for compounds with high melting points, thermal stability limitations, or poor solubility in volatile solvents, conventional routes of hot… read more here.

Keywords: solid dispersions; drug; amorphous solid; particle ... See more keywords

Amorphous solid dispersions of weak bases with pH-dependent soluble polymers to overcome limited bioavailability due to gastric pH variability - An in-vitro approach.

Sign Up to like & get
recommendations! Published in 2019 at "International journal of pharmaceutics"

DOI: 10.1016/j.ijpharm.2019.04.034

Abstract: Several drugs are pH-dependent soluble weak bases with a poor solubility in the intestinal pH range. Additionally a variable gastric pH, which is a common issue in the population, potentially reduces the in-vivo performance due… read more here.

Keywords: dependent soluble; gastric variability; weak bases; solid dispersions ... See more keywords