Influence of Low-Molecular-Weight Excipients on the Phase Behavior of PVPVA64 Amorphous Solid Dispersions
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DOI: 10.1007/s11095-017-2316-y
Abstract: PurposeThe oral bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs) can be improved by the preparation of amorphous solid dispersions (ASDs) where the API is dissolved in polymeric excipients. Desired properties of such ASDs like… read more here.
Keywords: low molecular; solid dispersions; molecular weight; amorphous solid ... See more keywords
Development of Fast-Dissolving Amorphous Solid Dispersion of Itraconazole by Melt Extrusion of its Mixture with Weak Organic Carboxylic Acid and Polymer
Sign Up to like & getrecommendations! Published in 2018 at "Pharmaceutical Research"
DOI: 10.1007/s11095-018-2407-4
Abstract: PurposeThe purpose of this study was to explore the feasibility of developing amorphous solid dispersion (ASD) by inducing acid-base interaction at an elevated temperature using hot melt extrusion.MethodsItraconazole and glutaric acid, which do not form salt… read more here.
Keywords: melt extrusion; solid dispersion; itraconazole; amorphous solid ... See more keywords
Examination of dissolution ratio of β-carotene in water for practical application of β-carotene amorphous solid dispersion
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DOI: 10.1007/s13197-021-04991-z
Abstract: β-Carotene (BC) has an antioxidant effect that removes active oxygen in vivo and can reduce the risk of developing various diseases, but it is almost insoluble in water. Therefore, to develop highly effective BC functional… read more here.
Keywords: amorphous solid; water; carotene; dissolution ratio ... See more keywords
A novel amorphous solid dispersion based on drug-polymer complexation.
Sign Up to like & getrecommendations! Published in 2020 at "Drug delivery and translational research"
DOI: 10.1007/s13346-020-00869-3
Abstract: Rafoxanide (RAF) is a poorly water-soluble drug that forms a complex with povidone K25 (PVP) in a cosolvent system containing acetone and an alkaline aqueous medium. This study aims to investigate the impact of RAF-PVP… read more here.
Keywords: raf; drug polymer; complexation; drug ... See more keywords
Cellulose based polymers in development of amorphous solid dispersions
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DOI: 10.1016/j.ajps.2018.09.003
Abstract: Cellulose derivatives have gained immense popularity as stabilizers for amorphous solid dispersion owing to their diverse physicochemical properties. More than 20 amorphous solid dispersion-based products that have been approved for marketing consist of cellulose derivatives… read more here.
Keywords: solid dispersion; solid dispersions; cellulose derivatives; cellulose based ... See more keywords
Interfacial interaction track of amorphous solid dispersions established by water‐soluble polymer and indometacin
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2017.05.067
Abstract: Abstract The present work studied interfacial interactions of amorphous solid dispersions matrix of indometacin (IMC) that established using PVP K30 (PVP) and PEG 6000 (PEG) by focusing on their interaction forces and wetting process. Infrared… read more here.
Keywords: contact angle; water; solid dispersions; amorphous solid ... See more keywords
Amorphous solid dispersion of cyclosporine A prepared with fine droplet drying process: Physicochemical and pharmacokinetic characterization.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.01.018
Abstract: The present study aimed to develop an amorphous solid dispersion (ASD) of cyclosporine A (CsA) by a fine droplet drying (FDD) process for improvement in oral absorption of CsA. CsA and hydroxypropyl cellulose-SSL were dissolved… read more here.
Keywords: droplet drying; solid dispersion; amorphous solid; asd csa ... See more keywords
Building a better particle: Leveraging physicochemical understanding of amorphous solid dispersions and a hierarchical particle approach for improved delivery at high drug loadings
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.01.009
Abstract: &NA; Amorphous solid dispersions are a promising option for managing compounds with poor aqueous solubility. However, for compounds with high melting points, thermal stability limitations, or poor solubility in volatile solvents, conventional routes of hot… read more here.
Keywords: solid dispersions; drug; amorphous solid; particle ... See more keywords
Amorphous solid dispersions of weak bases with pH-dependent soluble polymers to overcome limited bioavailability due to gastric pH variability - An in-vitro approach.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.04.034
Abstract: Several drugs are pH-dependent soluble weak bases with a poor solubility in the intestinal pH range. Additionally a variable gastric pH, which is a common issue in the population, potentially reduces the in-vivo performance due… read more here.
Keywords: dependent soluble; gastric variability; weak bases; solid dispersions ... See more keywords
Electrospun amorphous solid dispersions of meloxicam: influence of polymer type and downstream processing to orodispersible dosage forms.
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DOI: 10.1016/j.ijpharm.2019.118593
Abstract: The objectives of this work were to develop meloxicam based amorphous solid dispersion through electrospinning technique and evaluate the effect of the polymeric matrix on the physicochemical properties of the fibers and the downstream processing… read more here.
Keywords: downstream processing; solid dispersions; amorphous solid; dosage forms ... See more keywords
The influence of crushing amorphous solid dispersion dosage forms on the in-vitro dissolution kinetics.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.118884
Abstract: Solid dosage forms of amorphous solid dispersions (ASDs) have rarely been assessed for their crushability, although it might possibly be a more frequent practice than thought to facilitate oral administration in several clinical conditions (e.g.… read more here.
Keywords: crushing amorphous; solid dispersion; amorphous solid; influence crushing ... See more keywords