Preparation and tableting of long‐term stable amorphous rutin using porous silica
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2016.11.009
Abstract: Graphical abstract No caption available. Abstract Amorphous state of drugs increases the oral bioavailability, but typically faces physical stability problems. Amorphous rutin was generated and physically stabilized by encapsulating inside mesopores of porous AEROPERL® 300… read more here.
Keywords: microscopy; amorphous state; aeroperl 300; 300 pharma ... See more keywords
smartPearls – Novel physically stable amorphous delivery system for poorly soluble dermal actives
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.11.018
Abstract: Graphical abstract Figure. No caption available. Abstract Dermally applied poorly soluble actives whether in cosmetics or pharmaceuticals show insufficient skin penetration. Especially actives being insoluble in both phases of dermal vehicles, i.e. water and oil… read more here.
Keywords: poorly soluble; smartpearls novel; soluble actives; delivery ... See more keywords
Amorphous nanoparticles by self-assembly: processing for controlled release of hydrophobic molecules.
Sign Up to like & getrecommendations! Published in 2019 at "Soft matter"
DOI: 10.1039/c8sm02418a
Abstract: More than 40% of newly developed drug molecules are highly hydrophobic and, thus, suffer from low bioavailability. Kinetically trapping the drug as a nanoparticle in an amorphous state enhances solubility. However, enhanced solubility can be… read more here.
Keywords: state; nanoparticles spray; amorphous state; drug ... See more keywords
Mechanism for Stabilizing an Amorphous Drug Using Amino Acids within Co-Amorphous Blends
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15020337
Abstract: Designing co-amorphous formulations is now recognized as a relevant strategy for improving the bioavailability of low-molecular-weight drugs. In order to determine the most suitable low-molecular-weight excipients for stabilizing the drug in the amorphous state, screening… read more here.
Keywords: amorphous state; amino acids; using amino; amorphous drug ... See more keywords