A novel lurasidone hydrochloride–shikimic acid co-amorphous system formed by hydrogen-bonding interaction with the retained pH-dependent solubility behavior
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DOI: 10.1039/d0ce00952k
Abstract: In this work, we report on a novel lurasidone hydrochloride (LH)–shikimic acid (SA) co-amorphous system (LH–SA). It was formed via hydrogen-bonding interaction between LH and SA using a solvent evaporation method. The formation of the… read more here.
Keywords: amorphous system; system; solubility; bonding interaction ... See more keywords
Dissolution Amelioration by Small Amounts of HPMC in the Difficult-to-solve Drug Combination Baicalein-imperatorin Co-Amorphous System: Dispersion and Crystallization Inhibition
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DOI: 10.1208/s12249-025-03245-x
Abstract: Drug-drug co-amorphous systems (CAS) represent an emerging co-delivery strategy for combination therapy. Current research primarily explores combinations of poorly water-soluble drugs with water-soluble counterparts, while CAS comprising exclusively poorly water-soluble drugs remains underexplored. Such systems… read more here.
Keywords: combination; dissolution; drug; amorphous system ... See more keywords
Valsartan/2-Aminopyridine Co-Amorphous System: Preparation, Characterization, and Supramolecular Structure Simulation by Density Functional Theory Calculation
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DOI: 10.3390/molecules29225467
Abstract: The objective of this work was to improve the solubility and discover a stable co-amorphous form of valsartan (VAL), a BCS class-II drug, by utilizing small molecule 2-Aminopyridine (2-AP) in varying molar ratios (2:1, 1:1,… read more here.
Keywords: system; amorphous system; supramolecular structure; functional theory ... See more keywords