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Published in 2018 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2018.07.016
Abstract: Graphical abstract Figure. No caption available. ABSTRACT Co‐amorphous drug delivery systems are attracting increasing attention in the pharmaceutical field, due to their promising potential to improve the solubility and bioavailability of poorly water‐soluble drugs. In…
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Keywords:
amorphous systems;
molar ratio;
physicochemical properties;
organic acids ... See more keywords
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Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119662
Abstract: Co-amorphous systems comprising low-molecular weight drugs and co-formers constitute an interesting approach to optimize pharmaceutical performance of drugs with low aqueous solubility. Within the different types of co-amorphous systems, the combination of a drug with…
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Keywords:
raman;
amorphous systems;
sodium;
situ ... See more keywords
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Published in 2023 at "Journal of Chemical Education"
DOI: 10.1021/acs.jchemed.3c00036
Abstract: The concept of co-amorphous systems is introduced in an integrated laboratory experiment, designed for advanced chemistry students, using solvent-free, environmentally friendly mechanochemistry. The dual-drug naproxen-cimetidine co-amorphous system (NPX-CIM) is investigated as an example of the…
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Keywords:
amorphous systems;
chemistry;
pharmaceutical amorphous;
introduction pharmaceutical ... See more keywords
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Published in 2020 at "Critical reviews in food science and nutrition"
DOI: 10.1080/10408398.2020.1836607
Abstract: Amorphous solid products have recently gained a lot of attention as key solutions to improve the solubility and bioavailability of poorly soluble nutraceuticals. A pure amorphous drug is a high-energy form; physically/chemically unstable and so…
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Keywords:
challenges opportunities;
delivery nutraceuticals;
amorphous systems;
delivery ... See more keywords
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Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24065533
Abstract: The objective of this study was to obtain co-amorphous systems of poorly soluble sinapic acid using amino acids as co-formers. In order to assess the probability of the interaction of amino acids, namely, arginine, histidine,…
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Keywords:
amino acids;
sinapic acid;
solubility;
sinapic ... See more keywords
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Published in 2023 at "Molecules"
DOI: 10.3390/molecules28062492
Abstract: In this work, the solid–liquid equilibrium (SLE) of four binary systems combining two active pharmaceutical ingredients (APIs) capable of forming co-amorphous systems (CAMs) was investigated. The binary systems studied were naproxen-indomethacin, naproxen-ibuprofen, naproxen-probucol, and indomethacin-paracetamol.…
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Keywords:
solid liquid;
liquid equilibrium;
equilibrium amorphous;
amorphous systems ... See more keywords