When More Is Less: Dual Phosphorylation Protects Signaling Off State against Overexpression.
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DOI: 10.1016/j.bpj.2018.08.019
Abstract: Kinases in signaling pathways are commonly activated by multisite phosphorylation. For example, the mitogen-activated protein kinase Erk is activated by its kinase Mek by two consecutive phosphorylations within its activation loop. In this article, we… read more here.
Keywords: signaling state; increasing amounts; protects signaling; amounts erk ... See more keywords