Pharmacokinetics of Amoxicillin and Clavulanate Potassium for Suspension (200 mg/28.5 mg) in Healthy Subjects: Sample Add Stabilizer Study and Food Effects
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1143
Abstract: The present study compares the pharmacokinetics of amoxicillin and clavulanate potassium suspension (200 mg/28.5 mg) during fasting and postprandial conditions, and the sample adds a stabilizer study. Two randomized, crossover trials were conducted in an… read more here.
Keywords: time; clavulanate potassium; potassium suspension; study ... See more keywords
The acute effects of azithromycin use on cardiovascular mortality as compared with amoxicillin–clavulanate in US Veterans
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DOI: 10.1002/pds.5451
Abstract: Azithromycin is a common first‐line antibiotic for respiratory infection; however, there is conflicting evidence regarding risk of cardiovascular death. We assessed cardiovascular and noncardiovascular mortality associated with azithromycin versus amoxicillin–clavulanate among US Veterans treated for… read more here.
Keywords: acute effects; mortality; effects azithromycin; amoxicillin clavulanate ... See more keywords
Effect of Enterococcus Faecium Strain SF68 on Gastrointestinal Signs and Fecal Microbiome in Cats Administered Amoxicillin-Clavulanate.
Sign Up to like & getrecommendations! Published in 2017 at "Topics in companion animal medicine"
DOI: 10.1053/j.tcam.2017.11.002
Abstract: Some cats develop vomiting or diarrhea during administration of some antibiotics such as amoxicillin-clavulanate but how often this occurs and the severity of disease is generally unknown. In people, one of the accepted indications for… read more here.
Keywords: enterococcus faecium; faecium strain; strain sf68; microbiome ... See more keywords
In Vitro and In Vivo Activity of Amoxicillin-Clavulanate Combined with Ceftibuten or Cefpodoxime Against Extended-Spectrum β-Lactamase-Producing Escherichia coli and Klebsiella pneumoniae.
Sign Up to like & getrecommendations! Published in 2022 at "Microbial drug resistance"
DOI: 10.1089/mdr.2021.0025
Abstract: Infections due to extended-spectrum β-lactamase (ESBL)-producing Enterobacterales are an increasingly common problem. For many of these infections, no oral treatment options are available. The activity of amoxicillin-clavulanate combined with ceftibuten or cefpodoxime was evaluated against… read more here.
Keywords: extended spectrum; cefpodoxime; spectrum lactamase; clavulanate ... See more keywords
MIC of amoxicillin/clavulanate according to CLSI and EUCAST: discrepancies and clinical impact in patients with bloodstream infections due to Enterobacteriaceae
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkw562
Abstract: Objectives To compare results of amoxicillin/clavulanate susceptibility testing using CLSI and EUCAST methodologies and to evaluate their impact on outcome in patients with bacteraemia caused by Enterobacteriaceae. Patients and methods A prospective observational cohort study… read more here.
Keywords: clsi eucast; failure; amoxicillin clavulanate;
Oral amoxicillin‐clavulanate for treating diabetic foot infections
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes"
DOI: 10.1111/dom.13651
Abstract: To assess amoxicillin‐clavulanate (AMC) for the oral therapy of diabetic foot infections (DFIs), especially for diabetic foot osteomyelitis (DFO). read more here.
Keywords: amoxicillin clavulanate; foot infections; foot; diabetic foot ... See more keywords
Evaluating the effect of metronidazole plus amoxicillin‐clavulanate versus amoxicillin‐clavulanate alone in canine haemorrhagic diarrhoea: a randomised controlled trial in primary care practice
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Small Animal Practice"
DOI: 10.1111/jsap.12862
Abstract: OBJECTIVES To investigate the benefit of supplementing amoxicillin-clavulanic acid therapy with metronidazole in dogs presenting to a primary care veterinary practice with severe haemorrhagic diarrhoea. MATERIALS AND METHODS Prospective randomised blinded trial on dogs presenting… read more here.
Keywords: therapy; primary care; amoxicillin clavulanate; haemorrhagic diarrhoea ... See more keywords
Evaluation of urine concentrations of amoxicillin and clavulanate in cats.
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DOI: 10.1111/jvim.15991
Abstract: BACKGROUND To characterize urinary isolates, the Clinical and Laboratory Standards Institute (CLSI) uses an amoxicillin breakpoint for cats based on plasma (not urine) drug concentrations (≤0.25 μg/mL), but a urine-specific breakpoint for dogs exists (≤8 μg/mL). OBJECTIVES… read more here.
Keywords: urine specific; concentrations amoxicillin; urine concentrations; amoxicillin clavulanate ... See more keywords
Efficacy of oral antibiotics for non-severe-exacerbations of bronchiectasis in children
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DOI: 10.1111/resp.13491
Abstract: Introduction Antibiotics are used routinely to treat bronchiectasis exacerbations. However, placebo‐containing RCTs are lacking and, in non‐severe (non‐hospitalised) cases, antibiotics might be unnecessary since many exacerbations are virus‐triggered. We tested our primary hypothesis that when… read more here.
Keywords: exacerbation; placebo; amoxicillin clavulanate; bronchiectasis ... See more keywords
Ammonium glycyrrhizin counteracts liver injury caused by lipopolysaccharide/amoxicillin-clavulanate potassium.
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DOI: 10.18632/oncotarget.18291
Abstract: We treated isolated chicken primary hepatocytes with lipopolysaccharide/amoxicillin clavulanate potassium (LPS/AC) to model liver injury and investigate its underlying mechanisms. We also used this model to assess the cytoprotective effects of compound ammonium glycyrrhizin (CAG)… read more here.
Keywords: lipopolysaccharide amoxicillin; ammonium glycyrrhizin; amoxicillin clavulanate; clavulanate potassium ... See more keywords
Microbiota-dependent influence of prebiotics on the resilience of infant gut microbiota to amoxicillin/clavulanate perturbation in an in vitro colon model
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2023.1131953
Abstract: Antibiotic exposure disturbs the developing infant gut microbiota. The capacity of the gut microbiota to recover from this disturbance (resilience) depends on the type of antibiotic. In this study, infant gut microbiota was exposed to… read more here.
Keywords: colon; amoxicillin clavulanate; microbiota; gut microbiota ... See more keywords