A Delicate Connection: c-di-AMP Affects Cell Integrity by Controlling Osmolyte Transport.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in microbiology"
DOI: 10.1016/j.tim.2017.09.003
Abstract: Bacteria use second-messenger molecules to adapt to their environment. Several second messengers, among them cyclic di-AMP (c-di-AMP), have been discovered and intensively studied. Interestingly, c-di-AMP is essential for growth of Gram-positive bacteria such as Bacillus… read more here.
Keywords: delicate connection; cell envelope; amp; amp metabolism ... See more keywords
Adaptation of Listeria monocytogenes to perturbation of c-di-AMP metabolism underpins its role in osmoadaptation and identifies a fosfomycin uptake system.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental microbiology"
DOI: 10.1111/1462-2920.16084
Abstract: The human pathogen Listeria monocytogenes synthesizes and degrades c-di-AMP using the diadenylate cyclase CdaA and the phosphodiesterases PdeA and PgpH respectively. c-di-AMP is essential because it prevents the uncontrolled uptake of osmolytes. Here, we studied… read more here.
Keywords: pdea pgph; cdaa; listeria monocytogenes; amp metabolism ... See more keywords