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   Articles with "ampa" as a keyword



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In the fast lane: Receptor trafficking during status epilepticus

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recommendations! Published in 2023 at "Epilepsia Open"

DOI: 10.1002/epi4.12718

Abstract: Status epilepticus (SE) remains a significant cause of morbidity and mortality and often is refractory to standard first‐line treatments. A rapid loss of synaptic inhibition and development of pharmacoresistance to benzodiazepines (BZDs) occurs early during… read more here.

Keywords: receptor trafficking; receptor; ampa; status epilepticus ... See more keywords
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AMPA induced cognitive impairment in rats: Establishing the role of endoplasmic reticulum stress inhibitor, 4‐PBA

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recommendations! Published in 2021 at "Journal of Neuroscience Research"

DOI: 10.1002/jnr.24859

Abstract: Glutamate excitotoxicity and endoplasmic reticulum (ER) recently have been found to be instrumental in the pathogenesis of various neurodegenerative diseases. However, the paucity of literature deciphering the inter‐linkage among glutamate receptors, behavioral alterations, and ER… read more here.

Keywords: ampa; endoplasmic reticulum; pba; cognitive impairment ... See more keywords
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Subunit-Specific Augmentation of AMPA Receptor Ubiquitination by Phorbol Ester

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recommendations! Published in 2020 at "Cellular and Molecular Neurobiology"

DOI: 10.1007/s10571-020-00809-2

Abstract: Excitatory neurotransmission relies on the precise targeting of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors to the neuronal plasma membrane. Activity-dependent ubiquitination of AMPA receptor (AMPAR) subunits sorts internalised receptors to late endosomes for degradation, which ultimately… read more here.

Keywords: glua2; ampa; phorbol ester; subunit ... See more keywords
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Neuronal calcium channel α1 subunit interacts with AMPA receptor, increasing its cell surface localisation.

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recommendations! Published in 2018 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2018.02.107

Abstract: Voltage-activated Ca2+ channels (Cav) play critical roles in excitable cells including neurons. Unlike the well-defined roles of Cav2 for pre-synaptic neurotransmission, the post-synaptic function of Cav2 is unclear. Based on our previous study demonstrating the… read more here.

Keywords: cav2 ampa; ampa; surface localisation; ampa receptor ... See more keywords
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Population Shift Mechanism for Partial Agonism of AMPA Receptor.

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recommendations! Published in 2019 at "Biophysical journal"

DOI: 10.1016/j.bpj.2018.11.3122

Abstract: α-amino-3-hydroxy-5-methyl-4-isoaxazolepropionic acid (AMPA) ionotropic glutamate receptors mediate fast excitatory neurotransmission in the central nervous system, and their dysfunction is associated with neurological diseases. Glutamate binding to ligand-binding domains (LBDs) of AMPA receptors induces channel opening… read more here.

Keywords: ampa; population shift; agonism ampa; ampa receptor ... See more keywords
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Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors

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recommendations! Published in 2018 at "Cell Reports"

DOI: 10.1016/j.celrep.2018.06.102

Abstract: Summary Lateral diffusion on the neuronal plasma membrane of the AMPA-type glutamate receptor (AMPAR) serves an important role in synaptic plasticity. We investigated the role of the secreted glycoprotein Noelin1 (Olfactomedin-1 or Pancortin) in AMPAR… read more here.

Keywords: noelin1 affects; ampa; lateral mobility; mobility ... See more keywords
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Glyphosate and AMPA distribution in wind-eroded sediment derived from loess soil.

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recommendations! Published in 2017 at "Environmental pollution"

DOI: 10.1016/j.envpol.2016.11.033

Abstract: Glyphosate is one of the most used herbicides in agricultural lands worldwide. Wind-eroded sediment and dust, as an environmental transport pathway of glyphosate and of its main metabolite aminomethylphosphonic acid (AMPA), can result in environmental-… read more here.

Keywords: ampa; wind eroded; glyphosate ampa; glyphosate ... See more keywords
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Concurrent gradients of ribbon volume and AMPA-receptor patch volume in cochlear afferent synapses on gerbil inner hair cells

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recommendations! Published in 2018 at "Hearing Research"

DOI: 10.1016/j.heares.2018.03.028

Abstract: &NA; The Mongolian gerbil is a classic animal model for age‐related hearing loss. As a prerequisite for studying age‐related changes, we characterized cochlear afferent synaptic morphology in young adult gerbils, using immunolabeling and quantitative analysis… read more here.

Keywords: ampa; cochlear afferent; volume; hair ... See more keywords
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Glyphosate and AMPA exposure in relation to markers of biological aging in an adult population-based study.

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recommendations! Published in 2021 at "International journal of hygiene and environmental health"

DOI: 10.1016/j.ijheh.2021.113895

Abstract: BACKGROUND/AIM Glyphosate, a broad-spectrum herbicide, and its main metabolite aminomethylphosphonic acid (AMPA) are persistent in the environment. Studies showed associations between glyphosate or AMPA exposure and several adverse cellular processes, including metabolic alterations and oxidative… read more here.

Keywords: glyphosate ampa; biological aging; ampa exposure; ampa ... See more keywords

Sip-1 mutations cause disturbances in the activity of NMDA- and AMPA-, but not kainate receptors of neurons in the cerebral cortex

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recommendations! Published in 2017 at "Neuroscience Letters"

DOI: 10.1016/j.neulet.2017.04.048

Abstract: Smad-interacting protein-1 (Sip1) [Zinc finger homeobox (Zfhx1b), Zeb2] is a transcription factor implicated in the genesis of Mowat-Wilson syndrome (MWS) in humans. MWS is a rare genetic autosomal dominant disease caused by a mutation in… read more here.

Keywords: sip1; ampa; nmda ampa; mutations cause ... See more keywords
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TARPs and AMPA Receptors: Function Follows Form

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recommendations! Published in 2017 at "Neuron"

DOI: 10.1016/j.neuron.2017.02.040

Abstract: In this issue of Neuron, Ben-Yaacov et al. (2017) dissect the interaction between AMPA receptors and auxiliary (TARP) subunits, revealing essential roles for the receptor transmembrane and cytoplasmic domains, as well as for the TARP extracellular… read more here.

Keywords: ampa; receptors function; tarps ampa; ampa receptors ... See more keywords