The Role of AMPARs Composition and Trafficking in Synaptic Plasticity and Diseases.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and molecular neurobiology"
DOI: 10.1007/s10571-021-01141-z
Abstract: AMPA receptors are tetrameric ionic glutamate receptors, which mediate 90% fast excitatory synaptic transmission induced by excitatory glutamate in the mammalian central nervous system through the activation or inactivation of ion channels. The alternation of… read more here.
Keywords: ampars composition; ampa receptor; synaptic plasticity; plasticity ... See more keywords
Spinal AMPA Receptor GluA1 Ser831 Phosphorylation Controls Chronic Alcohol Consumption-Produced Prolongation of Postsurgical Pain
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0639-7
Abstract: Previous studies have shown that excessive alcohol drinking is associated with chronic pain development; however, the molecular mechanism underlying this association is poorly understood. In this study, we investigated the effect of chronic alcohol consumption… read more here.
Keywords: alcohol consumption; ampa receptor; chronic alcohol; alcohol ... See more keywords
Neuronal calcium channel α1 subunit interacts with AMPA receptor, increasing its cell surface localisation.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.02.107
Abstract: Voltage-activated Ca2+ channels (Cav) play critical roles in excitable cells including neurons. Unlike the well-defined roles of Cav2 for pre-synaptic neurotransmission, the post-synaptic function of Cav2 is unclear. Based on our previous study demonstrating the… read more here.
Keywords: cav2 ampa; ampa; surface localisation; ampa receptor ... See more keywords
Oridonin is an antidepressant molecule working through the PPAR-γ/AMPA receptor signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.114136
Abstract: Oridonin is a diterpene compound that regulates the activity of PPAR-γ (peroxisome proliferator-activated receptor gamma) transcription factor. Cumulative evidence indicates that AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-type glutamate receptors (AMPARs) play an important role in the treatment… read more here.
Keywords: ppar; treatment; ampa receptor; receptor signaling ... See more keywords
Population Shift Mechanism for Partial Agonism of AMPA Receptor.
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical journal"
DOI: 10.1016/j.bpj.2018.11.3122
Abstract: α-amino-3-hydroxy-5-methyl-4-isoaxazolepropionic acid (AMPA) ionotropic glutamate receptors mediate fast excitatory neurotransmission in the central nervous system, and their dysfunction is associated with neurological diseases. Glutamate binding to ligand-binding domains (LBDs) of AMPA receptors induces channel opening… read more here.
Keywords: ampa; population shift; agonism ampa; ampa receptor ... See more keywords
AMPA Receptor Auxiliary Subunit GSG1L Suppresses Short-Term Facilitation in Corticothalamic Synapses and Determines Seizure Susceptibility
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107921
Abstract: SUMMARY The anterior thalamus (AT) is critical for memory formation, processing navigational information, and seizure initiation. However, the molecular mechanisms that regulate synaptic function of AT neurons remain largely unexplored. We report that AMPA receptor… read more here.
Keywords: gsg1l; subunit gsg1l; receptor auxiliary; ampa receptor ... See more keywords
Auxiliary subunits of the AMPA: The Shisa family of proteins.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in pharmacology"
DOI: 10.1016/j.coph.2021.03.001
Abstract: AMPA receptors mediate fast synaptic transmission in the CNS and can assemble with several types of auxiliary proteins in a spatio-temporal manner, from newly synthesized AMPA receptor tetramers to mature AMPA receptors in the cell… read more here.
Keywords: auxiliary proteins; family; ampa receptor; subunits ampa ... See more keywords
Positive AMPA receptor modulation in the treatment of neuropsychiatric disorders: a long and winding road.
Sign Up to like & getrecommendations! Published in 2021 at "Drug discovery today"
DOI: 10.1016/j.drudis.2021.07.027
Abstract: Teaser The development of AMPA receptor (AMPAR) modulators as therapeutics has been fraught with challenges. However, recent advances, such as novel chemokines and modulators and high-throughput screening approaches to drug discovery, hold considerable promise for… read more here.
Keywords: modulation; ampa receptor; drug; receptor ... See more keywords
Intrathecally administered perampanel alleviates neuropathic and inflammatory pain in rats.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.172949
Abstract: Chronic pain conditions such as neuropathic pain and persistent inflammatory pain are difficult to manage. Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors modulate nociceptive processing at the spinal dorsal horn. Previous studies have shown that intrathecal AMPA receptor… read more here.
Keywords: neuropathic inflammatory; inflammatory pain; pain; ampa receptor ... See more keywords
P.1.008 Differential role of phosphodiesterase inhibitors on AMPA receptor trafficking and downstream cyclic nucleotide signaling
Sign Up to like & getrecommendations! Published in 2018 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.12.026
Abstract: Previous studies have shown that the cGMP-selective PDE5 inhibitor, vardenafil, and the cAMP-selective PDE4 inhibitor, rolipram, could improve synaptic plasticity when they are applied in specific time windows [1,2]. Subsequently it is proposed that the… read more here.
Keywords: cltp; ampa receptor; nucleotide signaling; role ... See more keywords
Iridoids from Gardeniae fructus ameliorates depression by enhancing synaptic plasticity via AMPA receptor-mTOR signaling.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.113665
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Gardeniae fructus is a traditional Chinese herb which exerts antidepressant effect. However, its effective constituent and potential mechanism are still unknown. AIM OF THE STUDY To examine whether iridoids, a type of monoterpenoids… read more here.
Keywords: mtor signaling; ampa receptor; mtor; receptor ... See more keywords